65 results
Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia
To determine: 1) the incidence of type 2 diabetes mellitus in FCHL patients, normolipidemic relatives and their spouses2) the incidence of cardiovascular disease in FCHL patients, normolipidemic relatives and their spouses3) the prevalence of CESD…
The objective of this study is to investigate what the effects of LCZ696 or amlodipine are on insulin sensitivity as assessed by hyperinsulinemic euglycemic glucose clamp (HEGC) after 8 weeks of treatment. Furthermore, the effects on subcutaneous…
In this study we will assess the optimal analytical conditions for routine laboratory GDM screening in the Netherlands, possible discrepancies in clinical outcome due to (pre)analytical variation and the applicability of POCT testing in GDM…
To perform 31P-MRS during and after exercise using a specifically designed probe to determine variations in energy metabolism along the TA muscle in healthy humans subjects.
To standardize the procedures and analyses to support evaluation of glucose dependent insulin secretion in Type 2 Diabetes Mellitus in subjects with Type 2 Diabetes.
To investigate the time difference between the blood glucose excursion and the subsequent appearance of cerebral 13C glucose after intravenous glucose loading.
Overall objective:The overall objective is to test the hypothesis that GLP-1 receptor activation of CNS reward and satiety circuits occurs, in the context of food(-related) stimuli, and that this effect is altered in individuals with obesity and…
We propose a 2-week randomized controlled, single-blinded pilot study to compare the health effects of a Paleolithic diet and an isocaloric reference diet (based on the *Guidelines for a healthy diet 2006*) on markers of the MetS which are risk…
The objective of this study is to learn from young people with a chronic illness (diabetes or progressive muscular disease) who have found a balance between taking good care of their illness and having a good life. This study examines how these…
In this study we will assess the effects of exenatide on cardiac metabolism and function in patients with T2DM and CHF. We will address the following hypothesis: exenatide improves global cardiac function in CHF patients with T2DM, by favorable…
The purpose of the study is to standardize continuous glucose monitors for measuring blood glucose profiles during the day.
To determine whether a difference in resilience of inflammatory tone between healthy and prediabetic males can be identified with whole blood ex vivo LPS stimulation.
The objective of the study is to develop a biorepository from patients with extreme metformin intolerance to assess predictive biomarkers (clinical, genetic and genomic) of intolerance.
We hypothesize that impaired insulin uptake into skeletal muscle interstitium (thus decreased transendothelial transport of insulin) is impaired in patients with type 2 diabetes mellitus. This hypothesis will be addressed in the present study.
The aim of this study is to determine whether dopamine modifies the metabolic activity of BAT. Furthermore, we want to investigate the relation between the metabolic activity of BAT with energy expenditure and glucose tolerance in these individuals.
To study the adaptive capacity in relevant metabolic processes after a high fat challenge and oral glucose challenge in humans. It is expected that a test method that is generally applicable in clinical food research can be developed.
The presently proposed study aims to investigate how dairy proteins compare to vegetable protein and carbohydrate sources leads to glucose and insulin metabolism and substrate partitioning.
The aim of this study is the collection of clinical data to develop and test calibration, filtering and prediction algorithms to be embedded in the so-called *smart sensor* for the enhancement of continuous glucose monitoring outcomes. In particular…
The presently proposed study aims to investigate how different feeding frequencies lead to differences in glucose and insulin metabolism in impaired glucose tolerant (IGT) men.
1. To determine the nature and time course of the energy sensing machinery during starvation in humans.2. To correlate systemic adaptations with changes at the cellular level.