15 results
The purpose of the study is to investigate wether long-term resveratrol supplementation (6 months) leads to improved insulin sensitivity (estimated by Matsuda Index) in people with overweight/obesity. In addition we will investigate effects of…
To explore the inflammatory changes of a PCSK-9 inhibitor compared with placebo on postprandial lipemia and postprandial leukocyte activation, oxidative stress and endothelial function in men with type 2 diabetes mellitus.
The objectives of the study are 1) whether ResvidaTM is capable of increasing mitochondrial content and function in healthy obese subject, 2) whether the ResvidaTM induced increase in mitochondrial content and function is accompanied by a better fat…
To provide insight in the physiological significance and underlying mechanisms involved in the relation between gut microbiota, energy balance and insulin sensitivity in overweight men with impaired glucose homeostasis
To examine whether resveratrol supplementation in type 2 diabetic patients improves overall and muscle-specific insulin sensitivity by affecting mitochondrial fat oxidative capacity. Furthermore, we are interested is this also affects liver and…
Based on our hypothesis that differential availability of SCFA will be beneficial effects on substrate and energymetabolism, the following objectives have been and will be addressed:- In our previous study (METC 11-3-079, NL38679.068.11) we have…
Based on our hypothesis that orally ingested inulin is fermented into different SCFAs, and these SCFAs can have beneficial metabolic effects, we aim to address the following primary objective: To investigate the human metabolic effects of SCFA…
The aim of this study is to investigate the effect of different doses of vitamin D on postprandial leukocyte activation markers, oxidative stress and arterial stiffness in vitamin D deficient females.
Based on our hypothesis that differential availability of SCFA will have beneficial effects on substrate and energy metabolism, the following objectives will be addressed:In this pilot study we will validate whether rectal administration of SCFA is…
To obtain insight into the metabolic and lifestyle determinants of postprandial blood glucose responses and to establish the effect of macronutrient manipulation of a 12-week dietary intervention on blood glucose homeostasis in metabolically…
The primary objective is to study the effect on consecutive FMT on liver fat accumulation measured by Magnetic Resonance Images (MRI) LiverMultiscan at 12 weeks. Secondary objectives are weight, waist, blood pressure, metabolic parameters (including…
The primary objective is to evaluate the effect of UDCA and ezetimibe on cholesterol elimination assessed as total faecal sterol concentration. Secondary objective is to assess the effect of UDCA and ezetimibe on plasma lipid profile/composition.
Our study aims to identify unique Metabotypes among individuals with overweight at risk of T2DM and assess their response to a 1-year precision dietary macronutrient modulation. The objective is to provide proof-of-concept that this approach…
To examine whether resveratrol supplementation in first-degree relatives of type 2 diabetic patients improves overall and muscle-specific insulin sensitivity by affecting mitochondrial fat oxidative capacity. Furthermore, we are interested is this…
To explore the inflammatory changes of dapagliflozin compared with placebo on postprandial lipemia and postprandial leukocyte activation, oxidative stress and endothelial function in men with type 2 diabetes mellitus using insulin.