4 results
The research aims to identify avoidable and non-preventable factors, which contribute to the development of chronic tophaceous gout. In addition, the study aims to assess the consequences (quality of life, comorbidity) of tophi.
Primary objective:• To determine the range and mean population DPD and TS enzyme activity in human peripheral blood mononuclear cells in 20 healthy volunteers. Secondary objectives:• To determine the circadian rhythm of DPD and TS enzyme activity in…
The primary objective of the study is to prospectively determine whether fluoropyrimidine-induced toxicity is preventable by dose adjustment prior to start of the first administration based on the polymorphic status of the DPYD*2A polymorphism in…
The purpose of the study is to investigate how quickly and to what extent FYX-051 is absorbed, distributed, metabolized (converted) and eliminated from the body. The compound to be administered will be labeled with 14-Carbon (14C) and is thus…