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Immune response after Human Papillomavirus vaccination in patients with automimmune disease

Objective: The primary goal of the current study is to study the immunogenicity and safety of HPV vaccination in patients with an autoimmune disease. Based on retrospective analysis with other vaccines we hypothesize that patients with autoimmune…

Lean Body Mass as a determinant of docetaxel pharmacokinetics and toxicity (LEANDOC)

Primary objective:To determine which anthropometric parameters, LBM, total body weight (TBW) or BSA correlates best to docetaxel exposure (AUC). Secondary objectives:To determine if occurrence of docetaxel toxicity can be related to dose/LBM.To…

An exploratory, open label, single-arm study to evaluate the effect of Eligard® 6-month on biomarkers of disease in patients with metastatic prostate cancer

To explore the effect of Eligard® on the following prostate cancer biomarkers:• Testosterone in serum• Prostate Specific Antigen (PSA) in serum• Prostate Cancer Antigen (PCA3 score) in urine • PSA mRNA in blood/PBMC• PCA3 mRNA in blood/PBMC• TMPRSS2…

Pilot study: performance of the Progensa PCA3 test in post-oxytocin urine specimens

The primary objective is to determine the yield of prostate cells in the urine specimen after oxytocin nasal spray, using a urine specimen with no manipulation as a reference method.

Patient-controlled remifentanil analgesia (PCA) during oocyte retrieval for IVF/ICSI procedures

The main objective of this open-label, randomized clinical trial is to asses whether patient-controlled analgesia with remifentanil is more efficious and equally safe as pethidine as analgesic strategy during ultrasound-guided transvaginal oocyte…

Magnetic Resonance Imaging to diagnose endometriosis using Ablavar ®
as contrast agent - a feasibility study

Primary Objective: test the feasibility of Dynamic-CE-MRI using Ablavar ® as contrast agent to detect peritoneal endometriosis in women.Secondary Objective(s): # To assess the image quality of Ablavar ®-enhanced MRI in comparison to unenhanced MRI…

HSG versus HyFoSy: is there a difference in VAS-painscores between these two tubal patency tests?

To determine wether a HyFoSy is a less painful procedure compared to a HSG examination for tubal patency testing

Prospective, multicenter, randomized controlled trial towards identifying the optimal Cetrotide treatment protocol

To demonstrate whether an early fixed start antagonist protocol improves the live birth rate compared with a late fixed start antagonist protocol.

OIL - BASED CONTRAST VERSUS WATER BASED CONTRAST MEDIA IN THE DIAGNOSIS OF TUBAL PATENCY AT HYSTEROSALPINGOGRAPHY

To determine whether flushing of the fallopian tubes is more effective with an oil based contrast medium or a water based contrast medium in terms of ongoing pregnancy.

HPV testing and the long term risk at cervical disease

The primary objectives of our study are: - Determining the long-term predictive value of a positive HPV test for (pre)malignant cervical disease.- Determining the long-term protective value of a negative HPV test. - Determining the long-term…

A phase IV prospective, multicentre, randomized, open-label trial to assess the efficacy and safety of GONAL f® at a dose based on subject baseline characteristics determined according to the CONSORT calculator compared with a standard dose of GONAL f® 150 IU per day for ovarian stimulation in women undergoing assisted reproductive technology (ART)

The purpose of this trial is to compare the ovarian response in assisted reproductive technology (ART) subjects administered a GONAL-f® dose determined according to a calculator system versus a given standard GONAL-f® dose of 150 International Unit…

a retrospective longitudinal clinical cohort study to investigate HPV testing post-treatment and the risk of recurrence of (cervical) disease on the long term.

The primary objective is to determine the positive and negative predictive value of an hrHPV test after treatment for the development of recurrent (cervical) disease on the long term.

Laparoscopic versus open abdominal sacral colpopexy for vaginal vault prolapse.
A comparison of effectivity, quality of life and costs.

OBJECTIVE: It has been estimated that one in nine women will undergo a hysterectomy during lifetime. Up to 10% of these women will subsequently need surgical repair for vaginal vault prolapse thereafter. Sacral colpopexy is a generally applied…

VAginal NOTES versus Laparoscopic hysterectomy in Uterine Endometrioid Cancer (VALUE-study): a multicentre randomized trial.

To evaluate the duration of admission, feasibility, patient satisfaction and complication rate of vNOTES hysterectomy with BSO and compare it with laparoscopic hysterectomy with BSO in case of clinical stage 1 low grade endometrial cancer.

Is Hysterosalpingo-Foam Sonography (HyFoSy) a cost-effective alternative for hysterosalpingography (HSG) in assessing tubal patency in subfertile women?

The objective of this study is to assess the costs and effects of two strategiesof tubaI testing during the fertility work-up, one based on the new technique hysterosalpingo-foam sonography (HyFoSy) (innovative strategy) and the other on…

Determining the clinical relevance of the inTeraction between AprepitaNt aNd EtoposiDe; an observational pharmacokinetic study (TANNED-study)

To investigate the influence of aprepitant on the exposure to etoposide in TC patients treated with (B)EP.

Oil- based versus water-based contrast media for hysterosalpingography (HSG) in infertile women with unevaluated indications: a randomized controlled trial

This study has been transitioned to CTIS with ID 2024-512571-12-00 check the CTIS register for the current data. The objective of the proposed study is to assess the effectiveness and cost-effectiveness of the use of oil versus water-based contrast…

Pain in endometriosis and the relation to Lifestyle (PEARL). Effectiveness of a dietary intervention and cognitive behavioral therapy in endometriosis-associated pain

To investigate the effectiveness of an anti-inflammatory diet in reducing pain symptoms among patients with endometriosis and to explore whether the addition of CBT enhances this pain-reducing effect apart from the effect of CBT alone. The secondary…

Prediction of Response Of horMOnal Treatment in advanced and recurrent Endometrial cancer

Primary Objective: Validation of the response prediction algorithm to hormonal therapy defined as response rate, progression free survival (PFS) and clinical benefit rate (CBR). Secondary Objectives: • Health-related quality of life in patients with…

Determining the clinical relevance of the interaction between enzalutamide and the opioid morphine and the DOAC edoxaban to improve rational pharmacological care of patients with prostate cancer

This study has been transitioned to CTIS with ID 2024-517646-34-00 check the CTIS register for the current data. The objective of this study is to evaluate the effect of enzalutamide on morphine and edoxaban pharmacokinetics. This information is…