47 results
In breast-conserving surgery, there is evidence that approximately 30% of women receive a suboptimal or poor aesthetic outcome; however there is currently no standardised method of identifying these women.The PICTURE project aims to address these…
Objective(s): The primary objective of this study is to asses the dynamic vaginal pressure profile in two groups: 1) women diagnosed with dyspareunia and, 2) women with primary vaginismus. The secondary goal is to assess vaginal reflexes in women…
To explore the effect of Eligard® on the following prostate cancer biomarkers:• Testosterone in serum• Prostate Specific Antigen (PSA) in serum• Prostate Cancer Antigen (PCA3 score) in urine • PSA mRNA in blood/PBMC• PCA3 mRNA in blood/PBMC• TMPRSS2…
This is a protocol aimed at standardizing clinical care and the diagnostic approach in a carrier of a pathogenic IGSF1 mutation referred for hormonal analysis to the outpatient clinic.
The aim of the study is to determine whether prenatal and current exposure to environmental chemicals is associated with developmental outcome in adolescents. We will investigate whether this exposure is associated with the thyroid hormone…
1. To examine and describe the vaginal microcirculation in patients with VA in comparison to patients without VA2. To examine and describe the effect of treatment with local oestrogen on the vaginal microcirculation.
The PICTURE project aims to address these issues by providing objective tools, tailored to the individual patient, to predict the aesthetic outcome of local treatment. Using a combination of 3D photography and routinely acquired radiological images…
The aim of this project is to develop a comprehensive EORTC questionnaire for assessing sexual health for male and female patients with cancer. Given the lack of a sexual health related measure that can be used in clinical trials and in clinical…
The purpose of this study is to quantify the amount of menstrual bleeding in participants with menorrhagia and its correlation to the overall impact of health as measured by the Menorrhagia Questionnaire.
The primary aim of this study is to gain more insight on the impact of reconstructive surgery on circumcised women (type I, 2 & 3). This study may also used for theorizing about plastic surgery on women who are circumcised.
To show the effect of the HSP90 inhibitor AUY922 on HER2 expression by means of 89Zr-trastuzumab PET scanning. Primary endpoint: measurement of decreased HER2 expression compared to baseline. A decline is defined as a decrease of at least 30% in…
To evaluate the effect of HSP90 inhibition by AUY922 on VEGF by means of 89Zr-bevacizumab PET. Primary endpoint: measurement of decreased VEGF compared to baseline. A decline is defined as a decrease of at least 30% in mean Standardized Uptake Value…
Aim of the hereby proposed study is to evaluate the DA for FP on its effectiveness compared to treatment as usual (TAU) regarding outcomes of decision making and decision making processes. Primary outcome is decisional coflict.
To measure the impact of the two opposite communication styles (warm, empathic and cold, formal) on the neurophysiological changes (endogenous dopamine release) in the human brain using positron emission tomography (PET) neuroimaging. This is an…
Phase I: To investigate whether it is feasible to organize an international multi-centre pragmatic trial on individualised homeopathic add-on treatment using a semi-standardised algorithm in women with premenstrual disorders and usual care only. We…
The primary objective of this study is to asses the dynamic vaginal pressure profile in asymptomatic women. The secondary objective is to assess vaginal reflexes in asymptomatic women.
The objective of this observational study is the safe introduction of clinical applied IVM in The Netherlands. During this study, the number and quality of the oocytes and embryos will be studied as well as pregnancy development. Emphasis will be on…
The overall aim of this study is to examine, in adult female CCS in the Netherlands, the effects of treatment in general, and the effects of different types of treatment, doses of drugs, radiation sites and doses, and age at time of treatment, on: 1…
The hypothesis is that women who have the Ser680Ser (SS) variant of the FSH receptor genotype, in comparison with women with the Ser680Asn (NS) or Asn680Asn (NN) variant, are less sensitive to FSH and because of that need higher dosages of FSH when…
We intend to employ an ex vivo model of human implantation to study the factors involved in successful implantation. By linking parameters of successful implantation with embryo quality markers, we aim to improve embryo selection and IVF outcomes.…