41 results
The use of an interactive web-based Decision Aid reduces decisional conflict and increases patient satisfaction with information and care.
The aim of this study is to optimize patient selection, to improve treatment efficacy and to better visualize treatment outcome. The objectives of this study will be investigated using the same patient population. For the main endpoints we…
Objective of the study is to investigate whether couples with unexplained subfertility and a good prognosis have a significantly higher probability of naturally conceiving an ongoing pregnancy within six months if they are offered internet-based sex…
Main objective of this study is describing the functional morphology of the microcirculation of the endometrium.
Primary objective:- To assess the efficacy of niraparib in subjects with measurable mCRPC and who have either biallelic DNA-repair anomalies in BRCA (BRCA 1 and BRCA 2 or germline BRCA. Secondary objectives:- To assess the efficacy of niraparib in…
To evaluate whether expectant management for 6 months does not lead to a decrease in ongoingpregnancy rate leading to a live birth compared to 6 months IUI-OH.HYPOTHESIS We hypothesize that 6 months of expectant management does not result in…
Primary Objective* To demonstrate that avelumab given alone or in combination with Pegylatedliposomal doxorubicin (PLD) is superior to PLD alone in prolonging Overall Survival(OS) in patients with platinum -resistant/platinum-refractory ovarian…
To develop and evaluate an adaptive MRI-only workflow for the MR-linac treatment in breast cancer patients eligible for APBI, regional lymph node irradiation or a radiotherapy boost on tumor positive lymph nodes. Furthermore, to investigate whether…
Primary Objective: To assess the detection rate of 18 F-FDHT PET/CT in men with recurrent prostate cancer after radiotherapy who are candidates for local salvage treatment.Secondary Objective(s): To assess the detection rate and accuracy of 18 F-…
To establish the safety and effectiveness of the Sonata System in the treatment of symptomatic uterine fibroids.
The objective of the study is to evaluate the subjective and objective effectivity and safety of the laparoscopic sacrocolpopexy of 189 patients who underwent this procedure in the period August 2004 - December 2014 in the Diakonessenhuis Utrecht/…
Determination of tissue perfusion and dielelectric properties by MRI in women with cervical cancer.
Co Primary Objectives:1. To demonstrate that avelumab in combination with platinum based chemotherapy followed by avelumab maintenance (Arm C) is superior to platinum based chemotherapy alone followed by observation (Arm A) in prolonging progression…
To determine the efficacy (as assessed by rPFS) and safety of olaparib versus investigator choice of enzalutamide or abiraterone acetate in men with metastatic castration-resistant prostate cancer who have failed prior treatment with a new hormonal…
An explorative study, that will include 15 patients and 15 volunteers without pelvic floor disorders, will be conducted to evaluate the possibilities of an open 0.25T MRI- system to assess the pelvic floor and to get a better understanding of the…
The objective of this monocenter, single-blinded, randomised controlled trial is to evaluate the effectiveness and cost-effectiveness of the Duckbill polyp snare in comparison with the hysteroscopic morcellator.Hypothesis: We hypothesize that snare…
This study is to answer two questions. First the reliability and validity of the novel lavage method to screen on cervical cancer in combination with the clinically validated hrHPV and hypermethylation triage tests. Second the functionality and…
To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…
We aim to study the link between behavioural and psychological determinants and chlamydia (re-)infection, and to develop mathematical models for curable STI incorporating these determinants to be able to better estimate the impact of interventions.
Primary Efficacy Objective: To define the minimum effective dose (MED) of the oral dose of E4 by evaluating changes in frequency and in severity of moderate to severe vasomotor symptoms (VMS) within each treatment arm at week 4 and 12. Secondary…