56 results
To explore the extent of inter- and intrafraction anatomical changes of the tumour and surrounding normal tissues, throughout the full course of treatment, and to subsequently assess the impact of these changes on the nominal planned dose. This…
The aim of this study is to compare a reduced follow-up schedule of 4 visits among low-risk, early-stage endometrial cancer survivors, with the schedule according to the current Dutch guideline that includes 10 to 13 visits, on:Primary outcomes:1.…
Determine which anaesthetic technique (general anaesthesia in combination with TAP blockade versus general anaesthesia in combination with thoracic epidural analgesia)offers the most benefits, with respect to attenuation of the surgical inflammatory…
During this feasibility study will be analysed if endometrial cells by using tampons can be obtained during surveillance of women with Lynch syndrome and first degree relatives at 50% risk of the gene mutation who get annual surveillance in the…
Objective: The primary goal of the current study is to study the immunogenicity and safety of HPV vaccination in patients with an autoimmune disease. Based on retrospective analysis with other vaccines we hypothesize that patients with autoimmune…
To investigate the hypothesis that women with uterine prolapse stage 2 or more treated by laparoscopic sacrohysteropexy will have equal or lower recurrence rate of prolapse compared to women treated by vaginal sacrospinous hysteropexy.
In this controlled (studygroups from P05-095 will serve as controls) observational study, the effects of radiation therapy after nerve-sparing radical hysterectomy for early stage cervical cancer on sexual function, bladder and bowel function is…
The primary objective is to assess the differences in mobility of pelvic organs between three commonly performed treatment options for uterine descent (vaginal hysterectomy, vaginal sacrospinous hysteropexy and laparoscopic sacrohysteropexy). The…
This study is designed to determine the usability of the CollaGUARD adhesion barrier in gynecological surgery. The aim is to collect qualitative and quantitative data in a small number of subjects (pilot study) to gain information on the usability…
The objective of the MINI-trial is to compare the clinical effectiveness, quality of life, and cost-effectiveness of uterine artery embolisation (UAE) to MR guided focused ultrasound (MRgFUS) in pre- or perimenopausal women with symptomatic uterine…
The primary aim of this research project is to investigate the prevalence and bother of OAB before and after POP repair surgery and to determine changes in bladder function after surgery. Secondary aim is to identify predictors of persistence,…
To investigate the hypothesis that women with uterine prolapse stage 2 or more treated by sacrospinous fixation have equal or lower recurrence rate of prolapse than women with a vaginal hysterectomy.
To increase progression-free survival at 3 months.
In order to confirm and externally validate the novel panel of genes identified in our study (06/101/K) to be significantly predictive of recurrent implantation failure, we will recruit 50 additional subjects treated by IVF who have undergone at…
The primary objective of this study is to evaluate feasibility of performing MR-HIFU treatment of uterine fibroids in a Philips Sonalleve MR-HIFU system equipped with a Direct Skin Cooling device. Secondary objective is evaluation of safety.
To evelauate the clinical efficacy after 12 months using a composite outcome: absence of apical prolapse (st 0 or I), absence of bulge symptoms, and absence of reintervention in the treated vaginal compartments (apical and anterior)
SIGnificance of routine Hysteroscopy prior to a first 'in vitro fertilization' (IVF) Treatment cycle
The aim of the proposed study is to assess whether diagnosing and treating unsuspected intrauterine abnormalities by saline infusion sonography and/or routine office hysteroscopy prior to a first IVF/ICSI treatment cycle improves the cost-…
Genetic analysis of the familial inheritance pattern of the COL3A1 2209G>A polymorphism.
The primary objective of this study is to evaluate the anatomical success of the GYNECARE PROLIFT + M* system in women with symptomatic ICS POP-Q Stage III or IV, requiring surgical correction of pelvic organ prolapse (POP). Secondary objectives…
In this study we want to evaluate the safety, technical efficiency, and volume treatment capabilities of the Philips MR guided HIFU system in the treatment of patients with symptomatic uterine fibroids. This information is required for CE labelling…