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Effects of anaesthetic technique on inflammatory stress response following laparoscopic hysterectomy in endometrial cancer patients: general anaesthesia combined with Transverse Abdominal Plane blockade (TAP) versus general anaesthesia and thoracic epidural analgesia (TEA).

Determine which anaesthetic technique (general anaesthesia in combination with TAP blockade versus general anaesthesia in combination with thoracic epidural analgesia)offers the most benefits, with respect to attenuation of the surgical inflammatory…

Endometrial sampling with vaginal tampons during gynaecological screening in women with Lynch syndrome

During this feasibility study will be analysed if endometrial cells by using tampons can be obtained during surveillance of women with Lynch syndrome and first degree relatives at 50% risk of the gene mutation who get annual surveillance in the…

Prevalence of overactive bladder (OAB) in patients with pelvic organ prolapse (POP) and predictors of symptoms of OAB after surgical correction of POP.

The primary aim of this research project is to investigate the prevalence and bother of OAB before and after POP repair surgery and to determine changes in bladder function after surgery. Secondary aim is to identify predictors of persistence,…

Post Abortion Prevention of Adhesions.
Evaluation of hyaluronic acid (hyalobarier ® Gel Endo) .

The goal of the study is to determine if the use of Hyalobarrier® Endo prevents or reduces the chance of adhesions. We also would like to know how many woman become pregnant within the year and how the pregnancy goes.

Genetics of pelvic organ prolapse; identification of specific gene defects in patients and their family members.

Genetic analysis of the familial inheritance pattern of the COL3A1 2209G>A polymorphism.

Simultaneously performed measurement of vaginal innervation, pelvic floor activity and vaginal plethysmography before and after pelvic surgery.

1. Investigate the effects of gynecological pelvic surgery on vaginal innervation, vaginal vascularisation and pelvic floor tonus. 2. Investigate the effects of gynecological pelvic surgery on sexual and psychological well-being. 3. Investigate the…

Paradoxical and venous Gas Embolism During Hysteroscopic Surgery Detected by Trans Esophageal Echocardiography: A comparison using either bipolar or monopolar diathermia

To determine the incidence and grade of venous emboli and/or paradoxical gas emboli during hysteroscopy surgery using TOE. In addition, a comparison will be made using either bipolar or monopolar diathermia. Knowing the incidence and severity of…

An observational controlled study on vaginal blood flow and sexual functioning after early stage cervical cancer treatment

This study will investigate a comparison group of women treated with a conventional (non-nerve sparing) RHL for cervical cancer (CC) at the Academic Medical Centre (AMC). Together with the data collected of women treated with a nerve sparing radical…

TePA-study (Tertiary Prevention of morbus Asherman-study);Evaluation of placement of hyaluronic acid (hyalobarier ® Gel Endo) and placement of a intrauterine device without cu or hormones to maintain separation of the cavity and mechanically to prevent spontaneous recurrence of adhesions.

Does the installation hyaluronic acid (hyalobarier ® Gel Endo), in patients with M. Asherman reduces or prevents the incidence and severity (ESGE score/classification) of spontaneous recurrence of adhesion better then the IUD without Cu or hormones…

PREvention of intrauterine adhesion after hysteroscopic surgery with novel deGradable film

The objective of the present study is to evaluate the safety of Womed Leaf after hysteroscopic myomectomy and its potential efficacy in preventing IUA at second look hysteroscopy.

The Influence of Pelvic floor muscle function on pessary Treatment success in patients with pelvic Organ Prolapse

The ultimate objective is to optimize pessary treatment for all patients with pelvic organ prolapse (POP). To reach this goal, we need to learn more about the mechanisms behind success and failure of pessary treatment. Previous research suggested…

Niche development in the first year after a caesarean section
and the influence of preterm birth and preeclampsia

Primary Objective: * To evaluate the presence and time of occurrence of a niche in women who underwent a caesarean delivery Secondary Objective(s): * To evaluate changes of niche size and thickness of the residual myometrium over time* To determine…

Secondary Prevention of Morbus Asherman
Evaluation of endometrium stimulation with estrogen gestagen post hysteroscopic adhesiolysis

We want to stuudy if exogenous hormone administration (oral administration of estrogen and gestagen) starting immediately after successful hysteroscopic adhesiolysis, in patients with M. Asherman reduces or prevents the incidence and severity (ESGE…