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Repeat CT scans for evaluation of inter- and intrafraction motion and it*s effect on radiotherapy dose distribution during curative radiotherapy for pelvic tumours; An exploratory pilot study.

To explore the extent of inter- and intrafraction anatomical changes of the tumour and surrounding normal tissues, throughout the full course of treatment, and to subsequently assess the impact of these changes on the nominal planned dose. This…

Effects of anaesthetic technique on inflammatory stress response following laparoscopic hysterectomy in endometrial cancer patients: general anaesthesia combined with Transverse Abdominal Plane blockade (TAP) versus general anaesthesia and thoracic epidural analgesia (TEA).

Determine which anaesthetic technique (general anaesthesia in combination with TAP blockade versus general anaesthesia in combination with thoracic epidural analgesia)offers the most benefits, with respect to attenuation of the surgical inflammatory…

Endometrial sampling with vaginal tampons during gynaecological screening in women with Lynch syndrome

During this feasibility study will be analysed if endometrial cells by using tampons can be obtained during surveillance of women with Lynch syndrome and first degree relatives at 50% risk of the gene mutation who get annual surveillance in the…

An observational controlled study on vaginal blood flow and sexual functioning after early stage cervical cancer treatment

This study will investigate a comparison group of women treated with a conventional (non-nerve sparing) RHL for cervical cancer (CC) at the Academic Medical Centre (AMC). Together with the data collected of women treated with a nerve sparing radical…

MRI BASED HYPERTHERMIA TREATMENT PLANNING
An Investigation in Women with Cervical Cancer

Determination of tissue perfusion and dielelectric properties by MRI in women with cervical cancer.

The Post-Ablation Cavitary Evaluation (PACE) Clinical Trial;(A pilot, prospective, observational clinical trial to evaluate the uterine cavitary architecture of patients who have previously undergone endometrial ablation with the AEGEA Vapor System for treatment of heavy menstrual bleeding)

To determine the feasibility of hysteroscopically accessing and visualizing the uterine cavity greater than 24 months following a completed endometrial ablation with the AEGEA Vapor System

Evaluation of pelvic organ prolapse using upright magnetic resonance imaging

An explorative study, that will include 15 patients and 15 volunteers without pelvic floor disorders, will be conducted to evaluate the possibilities of an open 0.25T MRI- system to assess the pelvic floor and to get a better understanding of the…

MRI based prognostic biomarkers for treatment success of Minimal invasive treatment for Uterine Fibroids with Magnetic Resonance guided High Intensity Focused Ultrasound (MR-HIFU)

The aim of this study is to optimize patient selection, to improve treatment efficacy and to better visualize treatment outcome. The objectives of this study will be investigated using the same patient population. For the main endpoints we…

Study on shared decision making in choosing a treatment for pelvic organ prolapse

The use of an interactive web-based Decision Aid reduces decisional conflict and increases patient satisfaction with information and care.