68 results
In our previous studies using optical spectroscopy, both ex vivo and in vivo, most promising results were obtained for tissue diagnosis. Moreover, invasive procedures for biopsy or radiofrequency ablation in these tissues are all very common. Thus,…
The objective of this study is to assess the efficacy and safety of radium-223 dichloride in subjects with human epidermal growth factor receptor 2 negative (HER2 negative), hormone receptor positive breast cancer with bone metastases treated with…
To establish biomarkers in nipple aspirate fluid, follow them in time and link them to breast cancer development at its earliest stage in women at high risk for breast cancer. Threshold values of biomarkers will be determined that point to a…
The principal objective of the study is to determine if the performance of the new technique (magnetic tracer and magnetometer) is equivalent to the performance of the standard technique (patent blue dye and radioisotope, wire localization).The…
(1) to measure the forces resulting from typical mammographic compressions by decomposing them into a component exercised on the breast and a component exercised on adjacent body structures, (2) to determine how the proportion of these two…
The primary objective of the study is to gain insight in the short term and long term effects of the EFCT-ODA therapy on 1) dyadic coping abilities in the relationship and 2) relational satisfaction. Moreover, the process aspects of the ODA will be…
To test the feasibility of breast MR elastography and explore the viscoelastic parameters of (1) normal breast tissue, of (2) breast tumours and of (3) scar tissue in the breast after lumpectomy.
To investigate whether an adjunctive YBSR program added to standard care compared to standard care alone, can reduce:1.fatigue symptoms (primary objective)2.psychological distressand improve:3.health-related quality of life4.sense of coherence5.…
The objective of this study is to assess efficacy and safety of radium 223 dichloride in combination with exemestane and everolimus in subjects with human epidermal growth factor receptor 2 (HER2) negative, hormone receptor positive breast cancer…
Investigate the association between BRCA1/2-mutations, DNA damage, apoptosis and oocyte/embryo quality in immature germinal vesicle (GV) bearing oocytes, immature metaphase 1 (MI) and unfertilized mature metaphase 2 (MII) oocytes and affected early-…
In breast-conserving surgery, there is evidence that approximately 30% of women receive a suboptimal or poor aesthetic outcome; however there is currently no standardised method of identifying these women.The PICTURE project aims to address these…
Up front breast surgery in patients with primary distant metastatic breast cancer, will result in an improvement of the 2-year survival compared to the survival achieved with systemic therapy and delayed local treatment or systemic therapy alone.The…
Primary goal: determine the diagnostic quality of CE-MRI scans acquired in supine positionSecundary goal: determine the accuracy of deformable image registration between prone CE-MRI and non-CE-MRI in supine position as an alternative option
The PICTURE project aims to address these issues by providing objective tools, tailored to the individual patient, to predict the aesthetic outcome of local treatment. Using a combination of 3D photography and routinely acquired radiological images…
Primary Objective: Examining the value of ABVS in relation to current breast imaging techniques by: - comparison of ABVS findings with MRI findings. - comparison of ABVS findings with mammography and hand-held US. Secondary Objectives: - assessment…
Primary: To evaluate the effect of a dose increase to 40mg tamoxifen QD for 4 weeks in patients with at least one CYP2D6 variant allele and/or the presence of a CYP2D6 inhibitorSecondary:To evaluate the effect of concomitant use of (potential)…
The aim of the research up till now was, during a number of months, to examine a total of 500 participants referred for mammography to the AMC. The different parameters which are relevant to compression were measured. Particularly the influence of…
To investigate that in mamma surgery, regional infiltration with ropivacaine 0,75% added to general anaesthesia causes less postoperative pain, nausea and vomiting compared to general anaesthesia alone.
The aim of this study is to evaluate an intervention aimed at improving family disclosure of inherited cancer risks by 1) supporting counselees in what they experience as a necessary, but at times difficult, task and, consequently 2) provide more at…
The main objective of this feasibility study is to assess the treatment accuracy of MR-HIFU in patients with breast cancer using a dedicated MR-HIFU breast system. A secondary objective is to determine the safety.