23 results
Primary goal: determine the diagnostic quality of CE-MRI scans acquired in supine positionSecundary goal: determine the accuracy of deformable image registration between prone CE-MRI and non-CE-MRI in supine position as an alternative option
In our previous studies using optical spectroscopy, both ex vivo and in vivo, most promising results were obtained for tissue diagnosis. Moreover, invasive procedures for biopsy or radiofrequency ablation in these tissues are all very common. Thus,…
Primary Objective: Examining the value of ABVS in relation to current breast imaging techniques by: - comparison of ABVS findings with MRI findings. - comparison of ABVS findings with mammography and hand-held US. Secondary Objectives: - assessment…
Primary objective:To establish the accuracy of pretreatment 7T MRI to identify low-risk breast cancers. This will be done by identifying preoperative imaging-based characteristics related to risk factors of cancer relapse in the resection specimens…
Aim of this study is to confirm the results from ex vivo research in humans in a clinical setting. The objective is to perform optical spectroscopy measurements during surgical procedures in vivo, involving resection of either breast, liver or lung…
The main objective of this study is to determine the performance of whole breast scanning with ultrasound (WBUS), combined with MRI, in a yearly breast cancer screening program for high-risk women, compared to the current practice of the combination…
a) to analyze and optimize the image quality of this prototype 3D-scanner. b) to assess the potential of the 3D-scanner to detect lesions (benign and malignant) in the breast and c) to assess the potential to determine the localization of lesions in…
Up front breast surgery in patients with primary distant metastatic breast cancer, will result in an improvement of the 2-year survival compared to the survival achieved with systemic therapy and delayed local treatment or systemic therapy alone.The…
We hypothesize that CTC detection through diagnostic leukapheresis improves the detection rate among ER+, N+ primary breast cancer who have received 5 years of adjuvant endocrine therapy and will be a promising technique for risk classification in…
First, the threshold for the biomarkers of 31P-MRS will be determined. These biomarkers can indicate whether a patient with breast cancer benefit from the neoadjuvant chemotherapy (NAC). Then it is determined whether a (combination of) biomarker(s)…
The main objective of this project is to demonstrate the feasibility of DLSCT to detect breast cancer in women with dense breasts.
In this feasibility study, we will validate the value of the preoperative [89Zr]trastuzumab PET/CT imaging to identify HER2 positive primary breast cancer and the possibility to predict pathological complete response.
To develop and evaluate an adaptive MRI-only workflow for the MR-linac treatment in breast cancer patients eligible for APBI, regional lymph node irradiation or a radiotherapy boost on tumor positive lymph nodes. Furthermore, to investigate whether…
The main purpose is to investigate the safety, pharmacokinetics and feasibility of ONM-100 as an intra-operative optical tracer to detect tumors and metastatic lymph nodes in solid cancers. Moreover, the study will investigate the optimal dose of…
Early detecction of breast cancer in women with high risk of developing breast cancer with protein and glycan biomarkers.
Primary Objective: To study the feasibility of Velocity Selective Arterial Spin Labeling as a non-invasive technique for breast cancer screening by comparing image quality with DCE-MRI.Secondary Objectives: Comparing tumor characteristics and…
To test the feasibility of breast MR elastography and explore the viscoelastic parameters of (1) normal breast tissue, of (2) breast tumours and of (3) scar tissue in the breast after lumpectomy.
This study aims to develop a prediction rule for PMPS one year after breast surgery based on neurophysiological, psychological, and clinical parameters. Based on this prediction, individualized perioperative management and postoperative revalidation…
Primary goal: to assess the accuracy of a supine magnetic resonance imaging (MRI)-guided electromagnetic navigation system used for tumor marker implantation in breast cancer patients.Secondary goal: to assess the variability in target volume…
The principal objective of the study is to determine if the performance of the new technique (magnetic tracer and magnetometer) is equivalent to the performance of the standard technique (patent blue dye and radioisotope, wire localization).The…