107 results
Primary objectiveTo determine whether adding the MRI/US fusion technique using mpMRI images for directed biopsy of a ROI leads to a higher detection rate of PCa per patient compared to a systematic 12-core biopsy protocol including directed biopsy…
The overall goal of this study is to further validate and improve the sentinel node procedure for prostate cancer using ICG-99mTc-nanocolloid. The first objective aims at further validation of the sentinel node procedure for prostate cancer via…
The main objective is to evaluate the safety and tolerability of Ad[I/PPT-E1A] as an adjuvant treatment for localised prostate cancer before radical prostatectomy. A secondary objective is to explore the histopathological and immunological effects…
Our primary objective is to develop an easily assayable germline-based panel of biomarkers to aid in selecting prostate cancer patients for management with active surveillance. As a secondary objective, we tend to incorporate potentially promising…
The purpose of this study is to find out how well JNJ-56021927 works when it is given along with abiraterone acetate and prednisone to treat prostate cancer. The safety of JNJ-56021927 when used with abiraterone acetate will also be studied. How…
Primary Objective:To assess the ability of BR55 to identify area(s) of VEGFR2 expression in human prostate by ultrasound molecular imaging on the basis of a visual score in comparison with histopathology analysis (location based on expression of…
The overall objective of this phase I/II three-part study is to evaluate the benefit of 12 weeks once daily dosing with ASP9521 in a population of patients with metastatic castrate resistant prostate cancer (CRPC) who have failed one or more lines…
To investigate the additional value of MRI and MRI-guided biopsy in men with an elevated PSA in the general practitioners* (GP) practice regarding the detection of both insignificant and significant cancer, and reduced biopsies.
1. To construct a Dutch multicenter prospective biorepository for validation of biomarker and imaging products.2. To provide a Medical Technology Assessment (MTA) of newly developed biomarkers, contrast enhanced ultrasound and multimodality MR Iin…
Primary objective:To determine which anthropometric parameters, LBM, total body weight (TBW) or BSA correlates best to docetaxel exposure (AUC). Secondary objectives:To determine if occurrence of docetaxel toxicity can be related to dose/LBM.To…
Primary Objective: the primary objective of this study is to determine the feasibility of [18F]FDHT PET/CT for in vivo evaluation of bone metastases in prostate cancer. Active locations will be compared with those seen on conventional imaging (bone…
In this proposed study, we aim to test not only the safety and biodistribution of [68Ga]Sarabesin 3, but also its potential to visualise prostate cancer. If the peptide proves to be successful, a next study will be initiated to test the potential to…
In this research project it is investigated if abdominal ultrasound measurement of prostate volume performed by the GP is equivalent to the prostate volume measured by the transrectal ultrasound (TRUS) performed by the urologist. Also the effect on…
Primary Objective: - To determine the urodynamic effects of PAE on bladder outlet resistance (BOR), Qmax, bladder contractility, and post-void residual (PVR).Secondary Objective(s): - IPSS/QoL scores.- Prostate Volume.- Prostate Specific Antigen…
To explore the effect of Eligard® on the following prostate cancer biomarkers:• Testosterone in serum• Prostate Specific Antigen (PSA) in serum• Prostate Cancer Antigen (PCA3 score) in urine • PSA mRNA in blood/PBMC• PCA3 mRNA in blood/PBMC• TMPRSS2…
The primary objective is to determine the yield of prostate cells in the urine specimen after oxytocin nasal spray, using a urine specimen with no manipulation as a reference method.
Main objective of this study is to test the feasibility and to determine the short and medium term histological cancer control of focal therapy using MR-guided focal laser ablation therapy in the treatment of localised prostate cancer. Secondary…
The study will compare procedural and post procedural outcomes for photoselective vaporization of the prostate (PVP) and transurethral resection of the prostate (TURP). The study requires use of the CE marked GreenLight XPS* Laser System (GreenLight…
The primary objective of this study is to compare HistoScanningTM guided prostate biopsy with systematic biopsy in the detection of prostate cancer in men candidate for a first or second biopsy procedure.
The proposed project aims at implementing the available scientific knowledge for recommending biopsies or active treatment, respectively, at the individual level in Dutch urological practice. To this end we have developed an internet based decision…