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EXPLORATORY CLINICAL TRIAL USING BR55 TARGETED ULTRASOUND CONTRAST AGENT IN THE DETECTION OF PROSTATE CANCER BY MOLECULAR IMAGING OF VEGFR2

Primary Objective:To assess the ability of BR55 to identify area(s) of VEGFR2 expression in human prostate by ultrasound molecular imaging on the basis of a visual score in comparison with histopathology analysis (location based on expression of…

Randomized, Double-Blind, Phase 3 Trial to Compare the Efficacy of Ipilimumab vs
Placebo in Asymptomatic or Minimally Symptomatic Patients with Metastatic
Chemotherapy-Naïve Castration Resistant Prostate Cancer

The objective of this study is to compare the overall survival of patients with prostate cancer who are no longer responding to hormone therapy (castration resistant) and who have not yet received chemotherapy live longer (overall survival) when…

A Phase 3, Randomized, Double-Blind, Multicenter Trial Comparing Orteronel (TAK 700) Plus Prednisone With Placebo Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer That Has Progressed During or Following Docetaxel-based Therapy

Primary Objective:• To determine if orteronel plus prednisone improves overall survival (OS)Key Secondary Objectives: • To determine if orteronel plus prednisone improves radiographic progression-free survival (rPFS)• To determine if orteronel plus…

A Phase 3, Randomized, Double-Blind, Multicenter Trial Comparing Orteronel (TAK-700) Plus Prednisone With Placebo Plus Prednisone in Patients With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer

To determine if orteronel plus prednisone improves radiographic progression-freesurvival (rPFS)To determine if orteronel plus prednisone improves overall survival (OS)

Prostate Cancer Molecular Medicine

1. To construct a Dutch multicenter prospective biorepository for validation of biomarker and imaging products.2. To provide a Medical Technology Assessment (MTA) of newly developed biomarkers, contrast enhanced ultrasound and multimodality MR Iin…

A pilot study to compare HistoScanning guided prostate biopsy with systematic biopsy in the detection of prostate cancer.

The primary objective of this study is to compare HistoScanningTM guided prostate biopsy with systematic biopsy in the detection of prostate cancer in men candidate for a first or second biopsy procedure.

Pilot study: clinical evaluation of biomarkers as predictors of survival in castrate-resistant prostate cancer patients.

The primary aim of this pilot study is to determine whether CTCs are a reliable predictor of survival in men with CRPC receiving docetaxel-based chemotherapy by using the Veridex CellSearch system and the biomarkers PCA3, TMPRSS2-ERG and biomarker…

MR-guided focal cryosurgery of the prostate: a pilot study*

Main objective of this study is to test the safety and feasibility of MR-guided focal cryosurgery in newly diagnosed prostate cancer patients and in patients with recurrent prostate cancer after radiotherapy. Secondary objectives are: to determine…