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A randomized, open label, Phase IIB trial of Optimal Sequencing of Treatment Options for Poor Risk Metastasized Castration Resistant Prostate Cancer Previously Treated with Docetaxel (OSTRICh trial)

Primary: * To assess Clinical Benefit Rate (CBR) in patients with mCRPC and poor prognostic factors treated with cabazitaxel or novel hormonal agents (abiraterone OR enzalutamide) as second-line therapy.Secondary: * To formally compare CBR in both…

In-vivo focal prostate imaging with confocal laser endomicroscopy and optical coherence tomography

Objective procedure 1:To assess the technical feasibility and safety of in-vivo focal imaging with CLE and OCT.Objective procedure 2: Primary Objective: To identify and define characteristics of prostate cancer on CLE and OCT and compare this with…

Pilot study to evaluate dosimetry and toxicity of lutetium-177-PSMA-617 radioligand therapy in low volume, hormone sensitive metastatic prostate cancer

The aim of this study is to evaluate the dosimetry and toxicity of Lutetium-177-PSMA-617, in patients with low volume, hormone sensitive metastatic prostate cancer.

Less injections by androgen scrutinisation

The primary objective of this study is to determine the possibility to extend the dosing interval of goserelin 10.8 mg with a testosterone-based dosing regimen compared to regular treatment with 3-monthly based goserelin 10.8 mg injections. This…