28 results
Primary objective: 1) To examine the effect of IGSF1 deficiency syndrome on semen quality when compared to WHO reference ranges;2) The comparison of semen quality of these patients to that of healthy controls.To investigate the association between…
In view of this lack of evidence and strong practice variation we propose a randomized clinical trial in overweight and obese subfertile women, in which we compare the costs and effects of a six months structured lifestyle program, aimed at weight…
The overall objective of this study is to examine specific cardio-metabolic and cardiovascular parameters in women of subfertile couples. This study protocol is divided in 3 studies to evaluate several cardio-metabolic/cardiovascular parameters in…
To preserve testicular tissue of young boys with cancer for possible autologous transplantation in the future if infertility has become apparent.
To test The Selection Failure hypothesis by assessing A) the degree of embryo invasiveness and decidual acceptance (the quality of decidualization, endometrium-embryo communication and endometrial stromal cell (ESC) migration) and B) the angiogeneic…
We aim to: 1) Characterize differences between paternal and maternal chromatin organization and pericentric heterochromatin formation after fertilization and during pre-implantation embryo development. 2) Analyze if this asymmetry affects formation…
The primary aim of this study is to examine/determine the effect of Totally ExtraPeritoneal (TEP) endoscopic hernia repair on male fertility. To measure this outcome, we examine testicular perfusion, volume, semen quality and blood levels of…
Fertility follow-up of the women who visited our out patient ward for information on fertility preservation before starting gonadotoxic treatment
Primary objective:To evaluate variations of androgenicity and androgen (re) activity in (apparently) eugonadal females by using CAG repeat length polymorphism ([CAG]n) of the androgen receptor, free testosterone levels, 2D:4D ratio and attention for…
The objective of this study is to evaluate a new and less invasive method of PGS. The new PGS technique will analyse a nucleus of a blastomere that was obtained by nuclear extraction rather than by biopsy of a whole blastomere.
1. To prevent multiple pregnancies and the concomittant neonatal mortality and morbidity while retaining acceptable delivery rates in couples with unexplained subfertility or mild male subfertility and poor fertility prospects. 2. To assess the…
We will assess the correlation between the incidence of early pregnancy loss and the successrate of ART in women with unexplained infertility. We will also investigate the difference in the incidence of early pregnancy loss in women with unexplained…
The first objective of this study is to test the hypothesis that a higher dose to the IPAs and corpora cavernosa is correlated to ED after EBRT. The second objective is to test the hypothesis that RIF in the IPAs and corpora cavernosa is correlated…
The purpose of this study is to investigate whether the hyperactive pelvic floor syndrome can be assessed by objective measurement. This will be done by means of a newly developed instrument, the so-called VPA/EMG/sensibility-combiprobe, that…
The objective of this study is to investigate the intra-individual change in AMH levels over several years in female RA patients.
The aim is to evaluate long-term (+/- five years post-intervention) follow-up results of a previously completed study that investigated the effect of a three-component (diet, exercise, cognitive behavioural therapy (CBT)) lifestyle intervention with…
1. To assess the prevalence of severe male subfertility in adult male survivors of childhood cancer in relation to type and intensity of treatment and age at time of treatment. 2. To assess the diagnostic value of inhibin B and AMH for the…
This DCOG-LATER project proposal aims to characterize the overall, disease and treatment-related risks of sexual dysfunction and delays in psychosexual development in a Dutch cohort of 5-year CCS treated in the period 1960-2001 and to evaluate the…
To asses whether endometrial scratching increases live birth rates in couples with unexplained infertility and a good prognosis (Hunault>30%)?
We hypothesize that one possible mechanism may involve the free radical formation. Therefore, measuring free radical generation will be correlated to the diversity of seminal microbiota and related with semen-parameters defined by the WHO guidelines…