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A single blind, randomized, cross-over placebo controlled dose finding study to investigate the pharmacokinetic profile of 3 doses of sublingual testosterone solution and their effect on physiological and subjective arousal in healthy, sexually functional premenopausal women.

Primary objectives:To establish the lowest effective dose using physiological and subjective measures of sexual arousal.To evaluate and compare the pharmacokinetics of testosterone and its metabolites following administration of three (3) doses (0.…

A rising multiple dose study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered SCH 900389 in healthy females (P07036)

To investigate the safety and tolerability of the test compoundTo study how the test compound is absorbed, broken-down and excreted by the bodyTo study the effect of the test compound on the functioning of the body, particularly the ovaries and sex…

The maternal-embryo interaction and its role in the etiology of recurrent miscarriages

To test The Selection Failure hypothesis by assessing A) the degree of embryo invasiveness and decidual acceptance (the quality of decidualization, endometrium-embryo communication and endometrial stromal cell (ESC) migration) and B) the angiogeneic…

A double blind, randomized, cross-over placebo controlled study to investigate the efficacy of sublingual testosterone solution on physiological and subjective arousal in healthy, sexually dysfunctional premenopausal women.

Primary objectives:To confirm the lack of effect of 0.5 mg sublingual testosterone on physiological and subjective measures of sexual arousal in women with HSDD. Secondary objective:To confirm the lack of effect of 0.5 mg sublingual testosterone on…

Patient-controlled remifentanil analgesia (PCA) during oocyte retrieval for IVF/ICSI procedures

The main objective of this open-label, randomized clinical trial is to asses whether patient-controlled analgesia with remifentanil is more efficious and equally safe as pethidine as analgesic strategy during ultrasound-guided transvaginal oocyte…

The influence of laparoscopic hernia repair on male fertility

This study is a pilot study to examine the presence of antisperm antibodies after laparoscopic groin hernia repair in men. The hypothesis of this pilot study is: After laparoscopic groin hernia repair with a mesh, antisperm antibodies can be…

Male Infertility After Totally ExtraPeritoneal Hernia Repair (TEP)

The primary aim of this study is to examine/determine the effect of Totally ExtraPeritoneal (TEP) endoscopic hernia repair on male fertility. To measure this outcome, we examine testicular perfusion, volume, semen quality and blood levels of…

Genital and subjective sexual response in women after close rectal restorative proctocolectomy with ileal pouch anal anastomosis: a comparative clinical study

To assess whether close rectal restorative proctocolectomy with IPAA has a better outcome regarding postoperative vaginal vasocongestion and reported psychological and sexual functioning then IPAA by TME restorative proctocolectomy.

Two-Center, In-Patient, Randomized, Placebo and Active Comparator Evaluation of the Pharmacokinetics (PK) and Safety, Along with Initial Pharmacodynamic (PD) Efficacy of Three Dose Levels of TBS-2 Intranasal Gel Applied Twice-Daily (BID) for up to Three Days in Female Patients with Hypoactive Sexual Desire Disorder (HSDD) or Anorgasmia (ANOR).

This clinical trial is being performed to evaluate the PK profile of TBS-2 administered as single and multiple (BID) doses in patients with HSDD or ANOR. In addition, the study will evaluate the initial PD efficacy and safety of intranasal TBS-2 BID…

Identification of psychometric and biological markers to assess androgen and serotonergic sensitivity in relation to sexual functioning in women.

Primary objective:To evaluate variations of androgenicity and androgen (re) activity in (apparently) eugonadal females by using CAG repeat length polymorphism ([CAG]n) of the androgen receptor, free testosterone levels, 2D:4D ratio and attention for…

Immobilisation or direct mobilisation after intrauterine insemination effects pregnancy rates?: A randomised controlled trial

To evaluate the effect of 15 minutes of immobilisation after IUI on the pregnancy rate

A prospective, randomized, double-blind, double-dummy, placebo- and active controlled, multicenter study assessing the efficacy and safety of the combination BAY 60 4552 / vardenafil compared to vardenafil (20 mg) for the treatment of erectile dysfunction not sufficiently responsive to standard therapy with PDE5 inhibitors

The primary objective of the study is to demonstrate the superiority of the combination BAY 60 4552 / vardenafil over vardenafil alone in the treatment of erectile dysfunction not sufficiently responsive to standard therapy with PDE5 inhibitors.The…

TOPFIT: Triptorelin Oral contraceptive Pill Flare-up in IVF/ICSI Treatment trial
The effect of a short, flare-up gonadotrophin-releasing hormone agonist versus antagonist treatment protocol in patients pre-treated with oral contraceptive pill on premature luteinizing hormone surges

The aim of the study is to show non-inferiority of a short, flare-up GnRH-agonist protocol to the GnRH-antagonist protocol, both with OC pill pre-treatment, in women undergoing in vitro fertilisation (IVF) or intracellular sperm injection (ICSI)…

Physical therapy for premature ejaculation - a pilot study

To study the results of pelvic floor physiotherapy for premature ejaculation.