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Among IVF patients undergoing fixed antagonist protocols with recombinant FSH, does administration of recombinant FSH from cycle day 5 onwards compared with cycle day 2 onwards, yield a higher number of good quality embryos?

The aim of the study is to determine whether cycle day (CD) 5 start of stimulation will lead to better quality of embryos, based on morphology, than CD 2 start, in IVF with GnRH antagonist co-treatment started on a fixed day.

A study of the effects of a novel ovarian stimulation regimen on embryo aneuploidy rates in IVF, and the impact of aneuploidy on implantation, as assessed in an in vitro model.

In this study we aim to compare the effect of two different ovarian stimulation protocols on embryo quality in a group of women of 39 years or younger, in a prospectively randomized controlled trial. PGS will be performed to assess chromosomal…

TOPFIT: Triptorelin Oral contraceptive Pill Flare-up in IVF/ICSI Treatment trial
The effect of a short, flare-up gonadotrophin-releasing hormone agonist versus antagonist treatment protocol in patients pre-treated with oral contraceptive pill on premature luteinizing hormone surges

The aim of the study is to show non-inferiority of a short, flare-up GnRH-agonist protocol to the GnRH-antagonist protocol, both with OC pill pre-treatment, in women undergoing in vitro fertilisation (IVF) or intracellular sperm injection (ICSI)…

Influence of Ribavirin and Interferon on Semen quality

To study the effect of peginterferon alpha and ribavirin on spermatozoa

Physical therapy for premature ejaculation - a pilot study

To study the results of pelvic floor physiotherapy for premature ejaculation.

A randomised controlled trial comparing in vitro maturation of oocytes with in vitro fertilisation in women with an increased risk of ovarian hyperstimulation syndrome.

Primary objective: To evaluate the cumulative live birth rate for two treatment strategies: 2 IVM/ICSI cycles versus 1 COH/IVF or COH/ICSI cycle.Secondary Objectives: To evaluate the health and development of IVM/ICSI children versus COH/IVF/ICSI…

Sexual (dys-)function in female childhood cancer survivors

Objectives1. To assess the prevalence of sexual dysfunction in a Dutch cohort of female childhood cancer survivors.2. To assess the disease-associated risk factors for sexual dysfunction (type of treatment, age at treatment) in female childhood…

A randomized, double blind, parallel group study of vardenafil flexible dose versus placebo in males with erectile dysfunction and their female partners* sexual quality of life. PARTNER II.

1. Success of maintenance of erection in men with ED.and 2. Improvement of their female partner*s sexual quality of life.

The feasibility of a physical activity program for men with lower urinary tract
symptoms and/or erectile dysfunction who show up at the OPD urology of the VU medical center with a lack of
physical activity.

1. determine how many male patients visiting the OPD urology for LUTS and/ or ED lack a certain amount of physical activity2. measure the willingness of those patients to follow a program for increasing their physical activity3. discover factors…

TREATMENT ALTERNATIVES FOR SUBFERTILE WOMEN WITH CLASS II ANOVULATION NOT CONCEIVING AFTER SIX OVULATORY CYCLES WITH CLOMIPHENE CITRATE

The purpose of this study is to assess the effectiveness of extended treatment with CC compared to treatment with gonadotropins and/or the use of intra-uterine insemination, in patients who had six ovulatory cycles after CC, but did not conceive.

Predictors of psychological distress in couples undergoing infertility treatment.

It is important that we get insight into which of the above mentioned factors are related to psychological problems. It could give us some important starting points for designing psychological intervention programs. Such an intervention could not…

Immunological determinants of human embryo implantation: an ex vivo model

We intend to employ an ex vivo model of human implantation to study the factors involved in successful implantation. By linking parameters of successful implantation with embryo quality markers, we aim to improve embryo selection and IVF outcomes.…

Implantation failure as a cause of unexplained infertility; determinants of the successrate in ART in women with unexplained infertility.

We will assess the correlation between the incidence of early pregnancy loss and the successrate of ART in women with unexplained infertility. We will also investigate the difference in the incidence of early pregnancy loss in women with unexplained…

A phase IV prospective, multicentre, randomized, open-label trial to assess the efficacy and safety of GONAL f® at a dose based on subject baseline characteristics determined according to the CONSORT calculator compared with a standard dose of GONAL f® 150 IU per day for ovarian stimulation in women undergoing assisted reproductive technology (ART)

The purpose of this trial is to compare the ovarian response in assisted reproductive technology (ART) subjects administered a GONAL-f® dose determined according to a calculator system versus a given standard GONAL-f® dose of 150 International Unit…

DOse volume effects and Fibrosis in the corpora cavernosa After Radiotherapy for prostate cancer
A pilot study

The first objective of this study is to test the hypothesis that a higher dose to the IPAs and corpora cavernosa is correlated to ED after EBRT. The second objective is to test the hypothesis that RIF in the IPAs and corpora cavernosa is correlated…

SIMULTANEOUS MEASUREMENT OF PELVIC FLOOR ACTIVITY, VAGINAL PLETHYSMOGRAPHY AND VAGINAL INNERVATION IN WOMEN WITH AND WITHOUT HYPERACTIVE PELVIC FLOOR SYNDROME.

The purpose of this study is to investigate whether the hyperactive pelvic floor syndrome can be assessed by objective measurement. This will be done by means of a newly developed instrument, the so-called VPA/EMG/sensibility-combiprobe, that…

Super ovulation in Intra uterine insemination: FSH or Clomifene citrate? The Super Trial.

To determine which ovarian hyperstimulation regimen (FSH or CC) should be applied in IUI in couples with unexplained subfertility or mild male factor subfertility.

TREATMENT ALTERNATIVES FOR SUBFERTILE WOMEN WITH CLASS II ANOVULATION NOT CONCEIVING AFTER SIX OVULATORY CYCLES WITH CLOMIPHENE CITRATE

The purpose of this study is to assess the effectiveness of extended treatment with CC compared to treatment with gonadotropins and/or the use of intra-uterine insemination (IUI), in patients who had six ovulatory cycles after CC, but did not…

Identifying the Need of Discussing Infertility Concerns Affecting Testicular cancer patients; an Evaluation

This study is designed to determine quality of care for the discussion of fertility concerns and cryopreservation after diagnosis and treatment for TC. The consult with health care providers where patients are informed about the risk of impaired…

The freeze-all strategy in IVF: who benefits?

To test the hypothesis that in women undergoing IVF/ICSI a freeze-all strategy results in higher ongoing pregnancy rates and is more cost-effective compared to a fresh embryo transfer.