Search for a trial

An open-label, multiple-dose, sequential, 2 treatment period study to evaluate the effect of QBW251 on the pharmacokinetics and pharmacodynamics of a monophasic oral contraceptive in pre-menopausal healthy female volunteers

- To assess the effect of QBW251 on the pharmacokinetics of a monophasic combined oral contraceptive containing 30 µg ethinyl estradiol (EE) and 150 µg levonorgestrel (LVG).- To assess the effect of QBW251 on the pharmacodynamics of a monophasic…

A Single-Dose, Open-Label, Randomized, 2-Way Crossover Pivotal Study to Assess the Bioequivalence of NGM/EE Tablets Manufactured at 2 Different Facilities

- To establish the bioequivalence of the hormones norgestimate, norelgestromin, and ethinyl estradiol in NGM/EE Schaffhausen tablets compared with the same hormones in NGM/EE Manati tablets.- To assess the safety and tolerability of both…

Systemic fibrinolysis in women with menorrhagia

Main: Investigate the cyclic variation in clot lysis time in women with HMB in comparison to controls. Secondary:- Investigate the cyclic variation in TAFI, PAI-1, tPA, PI, thrombin generation, fibrinogen, fibrin clot permeability and confocal…

Endometriosis diagnostics-Fusion MRI-ultrasound

To determine the feasibility of Fusion MRI-ultrasound for the uterus and ovary.To determine if Fusion MRI-ultrasound is more accurate for the diagnosis of endometiosis then MRI or ultrasound alone.