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A new approach to measure vaginal microcirculation

To investigate the feasibility of SDF imaging and spectrophotometry of the vaginal wall.

Effects of vaginal prolapse surgery on innervation of the vagina

1. To assess the effects of prolapse surgery on vaginal nerve density2. To measure the association between changes in vaginal nerve density and changes in pelvic floor function

Laparoscopic versus open abdominal sacral colpopexy for vaginal vault prolapse.
A comparison of effectivity, quality of life and costs.

OBJECTIVE: It has been estimated that one in nine women will undergo a hysterectomy during lifetime. Up to 10% of these women will subsequently need surgical repair for vaginal vault prolapse thereafter. Sacral colpopexy is a generally applied…

Topical 5% Imiquimod cream for vulvar Paget's disease: clinical efficacy, safety and immunological response

To assess the efficacy, evaluate the safety and immunological effect of topical 5% imiquimod cream for vulvar Paget*s disease and the quality of life during treatment.

A phase 2, randomized, double-blind, parallel-group study to assess the pharmacodynamics, safety/tolerability and efficacy of topical omiganan in patients with usual type vulvar intraepithelial neoplasia

Primary Objective• To explore the pharmacodynamic effects of topically applied omiganan • To explore the treatment effect of omiganan compared to placebo in uVIN patients Secondary Objectives• To assess safety and tolerability • To explore the…

Pedicled Peritoneum Vaginoplasty in feminizing genital Surgery; implementation according to IDEAL framework

Primary Objective: To assess the safety of the single flap peritoneum vaginoplasty procedure by studying adverse events and complications during, directly after and within 90 days of the operation. Secondary Objectives: - To assess short- (12 weeks…

Evaluation of two vaginal, uterussparing surgical methods for pelvic organ prolapse reconstruction: modified Manchester operation (MM) and sacrospinal hysteropexy (SSH).

Objective:The life-time risk for POP surgery is 20%, and 30% of these women will need surgery because of a recurrence. VaginalPOP surgery (VH, SSH and MM) is the first choice surgical treatment. The numbers of uterus sparing operations (SSH andMM)…

Robot-assisted laparoscopic laparoscopic colpectomy in female-to-male transgenders

feasability of a robot-assisted laparoscopic, single colpectomy in female-to-male transgenders who already had their uterus removed.

The feasibility of electromagnetic tracking for navigated placement of gynecological brachytherapy catheters

The primary objective of this study is to assess the feasibility of EM-navigation for gynaecological brachytherapy catheter placement.

5-AMINOLEVULINIC ACID PHOTODYNAMIC THERAPY FOR THE TREATMENT OF PREMALIGNANT DISORDERS OF THE VULVA

Primary objective: To assess the efficacy of low dose rate light fractionated aminolevulinic acid-Photodynamic Therapy (ALA-PDT) for treatment of VLS and HSIL. Clinical and histological response. Secondary objectives: Tolerence of ALA-PDT by…

Sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma. A multicentre observational study.

The primary objective is to investigate the safety of replacing complete IFL by the SLN procedure in patients with local recurrent vulvar squamous cell carcinoma without suspicious groin lymph nodes.

A phase 2, randomized, vehicle-controlled, double-blind study to explore the efficacy, pharmacodynamics and safety of topical ionic contra-viral therapy (ICVT) comprised of digoxin and furosemide in HPV-induced genital lesions of immunocompromised and immunocompetent patients.

Primary Objective• To explore the pharmacodynamics of the ionic contra-viral therapy CLS003 in immunocompromised and immunocompetent patients with benign and premalignant HPV-induced genital lesions.• To evaluate clinical efficacy of CLS003 compared…