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Step-down versus step-up analgesics in patients with (sub)acute sciatica in primary care

Primary Objective:What is the effectiveness of immediate opioid pain medication (followed by step-down) versus step-up pain medication within the treatment according general practitioners* clinical guideline in patients with (sub)acute sciatica,…

The effects of ceasing opioid, benzodiazepine, or Z-hypnotic drug use on measures of driving performance and postural balance.

The aim of this study is primarily to investigate the effects of a withdrawal intervention on measures of driving performance in a clinical population that uses benzodiazepines, Z-hypnotics, or opioid analgesics chronically. As a secondary objective…

Towards personalized dosing of natalizumab in multiple sclerosis

Our main objective is to prove that extending dose intervals guided by serum concentrations of natalizumab, will not result in radiological or clinical disease activity.

An Open-Label, Multi-Center, Follow-Up Study Designed to Evaluate the Long-Term Effects of Rasagiline in Parkinson's Disease Subjects who Participated in the ADAGIO Study

- To investigate whether the effect of early-start rasagiline treatment (according to the ADAGIO study protocol) provided long term benefits over delayed-start.- To investigate the long-term effects of rasagiline in PD subjects who participated in…

Measuring the effects of continuous dopaminergic stimulation on nocturnal movements in Parkinson's disease.

Primary:• To study the effect of rotigotine on nocturnal hypokinesiaSecondary:• To study the possibility of measuring nocturnal hypokinesia and its severity in a home setting• To correlate improvements in sleep quality by rotigotine with changes in…

A multi- center, randomized, cross-over study to demonstrate the efficacy of pudendal neuromodulation for the treatment of neurogenic overactive bladder

The purpose of this trial is to demonstrate the superior efficacy of pudendal neuromodulation in treating patients with neurogenic overactive bladder, who have failed conservative treatment, in a randomized cross-over trial.Symptoms of urinary…

A pilot study in patients with spastic gait to identify selectioncriteria for intrathecal baclofen therapy

Primary Objective: To study which test or which combination of tests has the best predictive value at baseline level for a positive effect of the ITB test-infusion, rated by the patient on the Patient-Global Impression of Change (P-GIC). Secondary…

International Second Immunoglobulin Dose in Guillain-Barre Syndrome patients with poor prognosis.

Primary objectiveTo determine whether a second IVIg dose in GBS patients with a poor prognosis improves functional outcome after 4 weeks.Secondary objectives To investigate whether: - a second IVIg dose in GBS patients with a poor prognosis improves…

A Multicenter, Open-Label Study to Evaluate Fatigue in Subjects With Relapsing-Remitting Multiple Sclerosis During Treatment With Tecfidera® (Dimethyl Fumarate) Gastro-Resistant Hard Capsules (TECNERGY)

Primary:The primary objective of this study is to determine whether DMF taken over 12 months is effective in reducing MS-related fatigue, as measured by mean changes in the Fatigue Scale for Motor and Cognitive Functions (FSMC), in subjects with…

Cost-effectiveness of minimal invasive spinal fusion compared to open fusion for patients with spinal stenosis with neurogenic claudication or radicular leg pain.

What is the cost-effectiveness of minimal invasive posterior lumbar interbody fusion in spinal stenosis patients, compared to the standard open fusion?

A long-term follow-up study for Multiple Sclerosis patients who have completed the alemtuzumab Extension Study (CAMMS03409)

To evaluate the long-term safety and efficacy of alemtuzumab, for patients already treated with this medicine in preceding clinical trials (CARE-MS I, CARE-MS II and CAMMS03409).

BETAEVAL GLOBAL- The new BETACONNECT auto-injector: Adherence and EVALuation of MS patients treated with Betaferon®

To better understand the utilities of the new BETACONNECT device and characterize its contribution to adherence, we plan to prospectively follow-up MS patients using the device for 24 weeks.

A multicenter, Single arm, Open label study of The Repeated Administration Of Qutenza For The Treatment Of Peripheral Neuropathic Pain.

The purpose of the study is to assess the safety and efficacy of repeated treatments of QUTENZA in subjects with peripheral neuropathic pain.

A multicentre, randomised, active comparator, parallel group study to compare the effect on cognition of adjunctive therapy with zonisamide versus sodium valproate.

Zonisamide (Zonegran) and sodium valproate (Epilim) are both medicines approved for the treatment of epilepsy. This study is intended to investigate to what extent zonisamide can affect your memory and concentration in comparison with sodium…

Motor function optimization in advanced Parkinson*s disease patients, combined with galantamine to prevent visual hallucinations.

To investigate the effects of galantamine on cognitive impairment and visual hallucinations in Parkinson`s disease, both therapeutic (direct effect) and preventive (protection against an acute increase of dopaminergic medication used by the patient…

Influence of S(+)-ketamine on Diffuse Noxious Inhibitory Control (DNIC) and offset analgesia (OA) in chronic pain patients (neuropathic pain, complex regional pain syndrome type 1, fibromyalgia) and healthy volunteers

1. Measure DNIC and offset analgesia in CRPS-1 patients, fibromyalgia patients and neuropathic pain patients;2. Compare DNIC and offset analgesia in chronic pain patients with DNIC and offset analgesia in healthy volunteers;3. Assess the effect of…

Botulinum toxin for treating calf muscle spasticity in Hereditary Spastic Paraparesis (HSP): functional effects on dynamic balance and gait

To show that an individually tailored treatment of the calf muscles with BTX-A promotes the balance capacity and mobility of HSP patients by an effective reduction of spasticity while preserving muscle strength. This explorative study uses a pre-…

Ambulation performance in chronic stroke patients using an implanted drop foot stimulator

The aim is to convince the rehabilitation community that drop foot after stroke can be functionallycorrected which increases significantly quality of life. The information will be spread throughrehabilitation centers targetting rehab physicians,…

Single arm study to assess comprehensive infusion guidance for the management of the infusion associated reaction (IARs) in Relapsing-Remitting Multiple Sclerosis (RRMS) patients treated with Lemtrada.

The objective of this study is to assess the distribution of infusion associated reactions (IARs) by severity grade when Lemtrada is administered to RRMS patients who will be medicated according to specified algorithm designed to manage infusion…

Prevention of renal and bladder damage in children with spina bifida by means of early injections with Botulinum-Toxin-A (Botox): a pilot study.

- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) prevent deterioration of the bladder and renal function?- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) decrease the need for an…