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Influence of methylphenidate on sleep and circadian rhythm in children with Attention-Deficit/Hyperactivity Disorder (ADHD)

Determine the influence of methylphenidate treatment on sleep-wake rhythm and endogenous melatonin rhythm.

BETAEVAL GLOBAL- The new BETACONNECT auto-injector: Adherence and EVALuation of MS patients treated with Betaferon®

To better understand the utilities of the new BETACONNECT device and characterize its contribution to adherence, we plan to prospectively follow-up MS patients using the device for 24 weeks.

A prospective, observational, multi-centre study investigating alterations of gut microbiome with its subsequent interaction on the brain-immune-intestine axis in patients with active relapsing remitting Multiple Sclerosis who start with oral treatment.

Primary Objective: To determine if the (change in) gut and oral microbiome at baseline or in the first 3 months after start of Cladribine is a predictor for treatment response in subjects with active relapsing remitting MS.The secondary objectives…

A 2-year Prospective Study to Assess Health-related Quality of Life in Subjects with Highly-Active Relapsing Multiple Sclerosis Treated with Mavenclad®

synopsis:Primary:• To assess the health related quality of life (HRQoL) through the MSQoL-54 scale in highly-active relapsing multiple sclerosis (RMS) subjects treated with Mavenclad® for 2 years (24 months)Secondary:• To assess treatment…