97 results
The primary objective is to measure the longitudinal changes of PDE10A enzyme availability in the caudate, putamen, and globus pallidus of Huntington*s Disease Gene Expansion Carrier (HDGECs) by comparison of the follow-up and initial Positron…
Primary Objective: The primary objective of this study is to evaluate safety and tolerability of pridopidine in patients with HD.Secondary Objectives: The secondary objectives of the study are to assess the effects of long-term, open-label dosing…
The primary objective is to assess the structural and functional segregation of the STN into its motor and non-motor regions in PD patients and healthy controls.The secondary objectives are:1. To compare the strength of the functional and structural…
The aim of this study is to assess whether a structured medication review in primary care improves medication adherence and leads to positive patient outcomes in patients with PD. The expectation is that the results of this study might be used to…
The purpose of the study is to investigate how quickly and to what extent UCB0599 and UCB2713 are absorbed, distributed, metabolized (broken down) and excreted from the body (this is called pharmacokinetics). Since UCB0599 and UCB2713 will be…
To develop well-described protocols for three tasks, i.e. a grasping task based on movement imagery, a button-press task, and a somatosensory finger mapping task, to be used in a larger ensuing clinical study by stroke patients in the 7T-MRI scanner…
To assess whether forward extension of both arms improves gait initiation in patients with PD, measured by faster coverage of the initial two meters of walking. Secondary objectives are to determine whether this change in performance can be measured…
To evaluate the safety of E2007 given as adjunctive, long-term treatment in patients with refractory partial onset seizures with or without secondary generalization that completed the E2007-A001-206 or the E2007-G000-208 studies (revised per…
Search for a relation between the concentration of haloperidol in serum and in liquor in elderly who reached a steady state of haloperidol. Secundairy aim: Cal inter-individual variation in serum and CSF concentrations, at the same dose haloperidol…
The primary objective of the research is to compare the physical disabilities of Parkinson*s patients using the Medido compared to patients taking their medication in the usual way. The secondary objectives are to compare for Medido versus regular…
To investigate the differences in driving performance and safety between CD patients and healthy controls in a driving simulator. To compare the subjective evaluation of the difficulty of various aspects of the driving task driving in CD patients…
The primary objective of this pilot study is to determine the effectiveness of four treatment options for local skin reactions induced by continuous subcutaneous apomorphine infusion, as compared to no treatment.The primary endpoint is the measured…
This research project exists out of two research questions:Firstly we will determine which gait parameters are associated with fall risk. Secondly develop a novel fall prevention program based on the associated fall risk gait parameters. To…
To replicate the dose-dependent D2-ligand displacing action of (-)-OSU6162 in the human brain and to determine the optimal dose of (-)-OSU6162 required to achieve a significant amount of D2-ligand displacement in humans.
The corticospinal spinal tract is an important descending pathway for control of hand muscles (Lemon, 2008). About 50 years ago, direct connections between the primary motor cortex and the motoneurons were discovered, but it is still a matter of…
Primary objective is to investigate whether a VF-based balance training program leads to improved balance control in PD patients and how posturographic outcomes are associated with changes in clinical outcome measures.Secondary objective is to…
The objective of this study is testing the efficacy, practical utility and user-friendliness of a trunk angle sensor and feedback device (Parkinson Assist, 2M Engineering Ltd) in the home setting of patients with Parkinson's disease with a…
Primary Objective: To study which test or which combination of tests has the best predictive value at baseline level for a positive effect of the ITB test-infusion, rated by the patient on the Patient-Global Impression of Change (P-GIC). Secondary…
Primary:To evaluate the feasibility of using unconjugated rotigotine saliva concentrations as a surrogate for unconjugated rotigotine plasma concentrations.Secondary :To evaluate the effect of time of food intake on rotigotine concentrations in…
The purpose of the study is to investigate how quickly and to what extent the study drug is absorbed, distributed, metabolized (broken down) and eliminated from the body.