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Cholinesterase inhibitors to slow progression of visual hallucinations in Parkinson*s disease: a multi-center placebo-controlled trial (CHEVAL)

investigate whether early treatment with ChEI delays the progression of minor VH to major VH without insight or PDP. In addition, we will measure motor control, psychotic symptoms, cognitive impairment, mood disorders, adverse events and compliance…

Pharmacokinetics and -dynamics of intrathecal baclofen therapy in patients with spasticity

Primary Objective: Studying the phenomenon of tolerance by evaluating pharmacokinetic- and dynamic parameters, in patients receiving long-term ITB therapy.Secondary Objective(s): 1.To specify the intrathecal pharmacokinetics and -dynamics of…

Levodopa in early Parkinson*s disease;LEAP-5Y-study:
Follow-up of the Levodopa in early Parkinson's disease study

To investigate whether early treatment with levodopa has a delayed beneficial effect on PD symptoms and functional health, and improves the ability to (maintain) work, reduces the use of (informal) care, caregiver burden, and costs. Additionally,…

Randomized trial comparing steered Deep Brain Stimulation with ring-shaped Deep Brain Stimulation for advanced Parkinson*s disease

To demonstrate that steered STN DBS is more effective than ring-mode DBS in reducing PD motor symptoms and to demonstrate that steered STN DBS has the potential to cause less stimulation-induces side-effects.

A multicenter double blind randomized crossover study comparing the impact of dorsal versus ventral subthalamic nucleus deep brain stimulation on apathy in Parkinson*s disease

In this study, we will test whether STN-DBS related apathy can be reversed by switching stimulation to a more dorsal contact on the electrode.