147 results
The main objective of this study is to evaluate the differences in [18F]FEOBV binding between PD patients and healthy control subjects, in order to evaluate the clinical feasibility of [18F]FEOBV as a cholinergic imaging ligand in PD. Secondary…
The main goal of the study is to evaluate the feasibility of using 1) passive treadmill belt speed perturbations to measure spinal reflex activity in the calf muscles; and 2) active real-time visual feedback on dedicated gait parameters to highlight…
Part 1: The primary objective is to investigate if the RNFL-ac in PD patients differs significantly from the RNFL-ac in healthy controls.Secondary Objectives are:1) to investigate if the RNFL-ac can be used to differentiate PD patients from healthy…
Primary Objective: • To investigate the difference in localization of the lesioned area in the brain towards the preoperative assessed target and relate this to registration and rating of clinical tremor.• To investigate the role of the dentato-…
This study is aimed to determine the efficacy of varenicline in reducing EDS in PD patients.
Primary objective of this study is to assess the reliability, validity, and diagnostic value of the neuromechanical parameters of joint impedance estimated by nonlinear SIPE technology in patients with a spastic paresis.
Our primary objective is to identify the disturbances in prosody, phonation and articulation with which dysarthria can be automatically recognized in speakers of Dutch, and German. To this end, we will first perform an experiment that involves the…
This project aims to determine the validity of a home-based continuous bradykinesia assessment using free typing behaviour analysis. Secondarily, we aim to capture the presence of sequence effect in Parkinson's Disease patients using a computer…
Objective: The primary objective of this study is to investigate whether pain experience decreases or increases when cognitive functions decline in patients with Parkinson's disease. Furthermore will be investigated whether this is influenced…
To assess the potential of the PET-tracer [11C]SMW139 to investigate the role of P2X7R, a cell surface receptor upregulated in activated microglia, in neuroinflammation in PD. The aim is to find the optimal tracer kinetic model which can be used to…
The main purpose of this research is to assess the interrater reliability (3 raters) of an instrumented clinical spasticity measurement. Also, the agreement will be determined between the instrumented and non-instrumented spasticity measurement.…
We aim to extend our recent work on fundamental mechanisms that underlie automatic influences of reward on attention to clinical populations that suffer from reduced and excessive reward-driven behaviours. That is, we will investigate whether…
-To confirm the potential of a diagnostic tool to discriminate dystonic from non-dystonic muscles in CD patients-To explore the potential to discriminate CD patients from Functional Torticollis (FT) patients
The main objective of this study is to characterize the features and the extent of extracerebellar structural pathology in SCA3 and SCA6 patients. Secondary objectives are:- To explore the sensitivity of DWI and other imaging modalities in detecting…
The main objective of this study is to evaluate whether the PowerGlove is a valid instrument that can be used for the assessment of hand motor symptoms in patients with Parkinson*s disease. Sensitivity, specificity, intra-examiner reliability and…
The aim of the study is to investigate the differences in multi-joint coordination between healthy young and healthy elderly. Secondly, we want to study adaptation of ankle and hip strategy with the application of whole-body force fields and…
1. We will recruit 6 probands who experience cerebellar movement disorders with spinocerebellar ataxia features such as uncoordinated movement (i.e. asthenia, asynergy, delayed reaction time and dyschronometria) in limbs and organs such as the eyes…
The main goal of this study is to investigate the side effects of deep brain stimulation in Parkinson's disease. An important aspect of these side effects is the reward-oriented behavior. For this reason, patients will be administered…
This study tests the ability of the Cue-shoe, a new cueing device, to provide patients with FoG with successful cueing.
The primary objective of this study is to define and evaluate the clinimetric properties of the SMT in terms of validity and reliability.