63 results
This project has three separate but complementary research objectives. First, to find out whether there is indeed evidence of subclinical cerebellar dysfunction in these subjects, by specifically focusing on cerebellar motor learning. Second, to…
To include Dutch subjects in a Canadian study to establish the frequency of intergenerational CAG size changes for individuals with an intermediate allele (27-35 CAG) for Huntington disease. This will allow us to understand the evolution of HD…
To examine the effect of tizanidine on the system characteristics of the reflex in the upper extremity
To determine the feasibility and applicability of the intervention 'Traject' to improve the participation in work of young adults (16-25 years) with a chronic disorder.
identification of the needs of families with juvenile Huntington's disease
The aim of this study is to gain understanding of the functioning of spinal reflexes in patients with MD, using a new method involving EMG, EEG and the wrist manipulator.
The prevalence of tics, tic-severity and quality of life in 50 patients with Tourette syndrome aged >50 years will be assessed.
Primary Objective: To determine the characteristics of the short-latency muscle response (SLR) in patients with Parkinson*s disease, in comparison to age-matched healthy controls.Secondary Objective(s): To correlate the characteristics of the SLR…
Our objective is to investigate how individual finger movements are controlled within a sequential task. To study the presence and changes over time of motor overflow, multi-channel EMG on both intrinsic and extrinsic hand muscles are used. Changes…
Our objective is to investigate how complex finger movements like fast sequences are controlled by the brain. Muscle activation patterns, studied by multi-channel EMG on both intrinsic and extrinsic hand muscles, and force traces are compared…
- To investigate the baseline profile and inter- and intra-subject within-day and between-day variability of the fatty-acid profiles including fatty-acid desaturation index (FA-DI) and PUFAs in the plasma of patients with Parkinson*s disease and…
Objective: to develop a FOG detection and prediction algorithm under free-living conditions.
We here validate the algorithms for movement analysis that were developed previously in healthy participants (METc 2019.542; regarding quantitative aspects of movement) and that were derived from a review of the literature (regarding qualitative…
Primary Objectives* To investigate the intra-variability (day-to-day) of glucocerebrosidase pathway biomarkers in HV, PD-GBA+ and PD-GBA-Secondary Objectives* To investigate the intra-variability (within-day) of glucocerebrosidase pathway biomarkers…
To sequence the GBA1 gene in Parkinson*s disease patients to identify possible participants for a possible future phase 1 trial. The gene will be described as wildtype (WT) or containing a mutation (GBA+); with record of the specific mutation. To…
The primary goal of this phase 0 study is to assess the variability of mitochondrial function measurements in healthy volunteers and PD patients.
To set up a trial*ready cohort by bringing together 7 European cohorts and 1 US cohortand include new subjects, which together comprise more than 800 subjects with the developmentand validation of innovative assessment instruments and disease…
The primary objective is to investigate whether Parkinson*s patients are able to produce an optimal inhalation technique for the Cyclops® inhaler in their home situation after first and second inhalation instruction. The secondary objective is to…
Primary Objective: • To chart longitudinal disease progression rates for SPG7 and ARSACS by a multisite, prospective natural history study. Secondary Objective(s): • Development of a new clinical SPAX composite scale.• To identify (a combined set of…
Primary Objective- To identify (a combined set of) clinical and non-clinical markers most sensitive to disease progression in Dutch SCA1 mutation carriers. Secondary Objectives:- To quantify the annual change in disease-relevant clinical scales and…