19 results
This study is aimed to determine the efficacy of varenicline in reducing EDS in PD patients.
Primary objective of this study is to assess the reliability, validity, and diagnostic value of the neuromechanical parameters of joint impedance estimated by nonlinear SIPE technology in patients with a spastic paresis.
The primary objective of this study is to assess the efficacy of Ecopipam to reduce self-injurious behaviors (SIB) in adults and children with Lesch-Nyhan Disease (LND) in an outpatient setting. The secondary objectives of this study are to assess…
The aims of this study are the ascertainment, characterization, and longitudinal follow-up of a large cohort of Dutch families segregating Parkinson*s disease, including affected and unaffected first-degree relatives. The cohort will be…
Our aim is to investigate whether patients who are informed by video will have less preoperative anxiety than the patients who receive usual information.
2. OBJECTIVESPrimary Objective: 1. Does conversion tremor show similar abnormal cerebral activation patterns compared to conversion pareses?Secondary Objective:1. Is decreased precuneus activity also present in conversion tremor?
Search for a relation between the concentration of haloperidol in serum and in liquor in elderly who reached a steady state of haloperidol. Secundairy aim: Cal inter-individual variation in serum and CSF concentrations, at the same dose haloperidol…
The main objective of this study is to develop a method to identify susceptible pathways of redox metabolism and bioenergetics in peripheral blood cells and induced pluripotent stem cells from patients with PD and DLB.
The primary aim of this study is to measure the effect of light therapy on mood in depressed Parkinson patients. In addition, we measure the effect of light therapy on sleep, motor functions, circadian rhythms and quality of life.
For a possible (better) treatment of FOG a better understanding of the brainmechanism behind this phenomenon is needed. Previous studies showed some brain areas that are possibly involved in FOG.The aim of this study is to see whether we can induce…
The aim of this study is to evaluate the influence of extreme fixed wrist flexion and ulnar deviation due to spasticity on bone shapes of the wrist bones. We want to compare CT scan-based three-dimensional reconstructions of the spastic wrist to the…
To demonstrate the extent to which an intervention that combines treadmill training augmented by virtual reality (TT+VR) reduces fall risk, improves mobility and enhances cognitive function in a diverse group of older adults, compared to a treadmill…
The aim of the study is to generate a validated questionnaire to measure dysphagia in the three different stages of Huntington's disease.
A better understanding of the underlying mechanisms of depression in Parkinson's disease will lead to better diagnoses, treatments, and quality of life.
to find evidence for frontal inhibition during planning of explicit movements just as seen in patients with conversion disorders.
To test the suitability of the PortaLite fNIRS device for measuring brain activity during dual tasking performed by elderly with Parkinson*s Disease (PD) and design a valid and feasible protocol for this measuring.
Our goal is to develop and validate a Movement Diagnostic System (MDS) to accurately locate specific CNS pathological changes in ET, PD-T and DYS, with the use of fMRI and scanner compatible EMG, accelerometry, video, and wrist perturbator.
The primary objective is to study the effects of 12 weeks of treadmill training with virtual reality on neural plasticity in comparison to the effects of treadmill training without virtual reality.Secondary objectives are to investigate the role of…
The aim of the study is to show safety and effectiveness of the Sapiens electrode in an acute, intra-operative setting.