20 results
The primary objective is to compare the effectiveness of ambroxol versus placebo on the MDS-UPDRS part III motor sub-score in the *practically defined OFF-medication state* in patients with moderate PD, carrying a GBA mutation. The hypothesis is…
The objectives of this study are: 1. to identify new genetic variants causing or predisposing to PD; 2. to characterize the clinical phenotype in PD associated to specific genetic variants; 3. to investigate the molecular mechanisms of PD in…
Because experimental evidence suggested the possibility to measure paratonia through muscle activity, the primary aim of this study is to develop an objective non-invasive tool based on surface electromyography (sEMG) to quantify the presence and…
Test whether a mindfulness-based cognitive therapy intervention (MBCT) improves psychological distress, clinical symptoms, slows neurodegeneration, and/or enhances neuroplasticity in PD.
To sequence the GBA1 gene in Parkinson*s disease patients to identify possible participants for a possible future phase 1 trial. The gene will be described as wildtype (WT) or containing a mutation (GBA+); with record of the specific mutation. To…
In this project we aim to evaluate whether a non-pharmacological and tailored intervention targeting anxiety- and stress-related FOG in people with PD is effective to reduce the impact of anxiety and stress on FOG. Specifically, we aim to study: (1…
The primary objective is to determine the feasibility of a remote intervention study to promote physical activity in people with iRBD. The secondary objectives are to determine the longitudinal effect of an exercise intervention in people with iRBD…
Primary Objective: To identify disease (Parkinson*s disease) specific alterations in neural control of breathing by using respiratory neurophysiological techniques.
The aim of this study is to develop and validate this much-needed Parkinson*s Disease-specific rating scale; the so-called *Movement Disorders Society Rating Scale: Postural Instability and Gait Difficulties (PIGD)*. This PIGD rating scale assesses…
The primary objective is to determine whether there is a difference in the capability of the patients to successfully follow the instructions of both the Levodopa Cyclops* and the INBRIJA® inhaler during an off episode, based on the instruction…
Objective: To study the effectiveness of pelvic physical therapy and ES in patients with PD suffering from LUTS. Which are the most effective parameters for ES. Intervention: Intervention: 8 treatment sessions of 30 minutes pelvic physical therapy…
The aim of this study is to assess whether the effectiveness of STN DBS for the treatment of Parkinson motor symptoms using imaging-based DBS programming is non-inferior compared to DBS programming with the current standard practice of clinical…
Primary Objective- Evaluate longitudinal intra-individual and inter-individual variability of PBMC biomarkers in healthy participants:o LRRK2 protein (pg/mL)o total protein (ug/mL)o pS935 LRRK2/total LRRK2 peptide ratioo pRab10/Rab10 peptide ratio…
To explore the safety, feasibility and net symptomatic effects of multiple intermittent hypoxia intervention sessions in individuals with PD. Secondary outcomes include exploring induction of relevant neuroprotective pathways as measured in serum.
Primary Objective: For the primary objective, the following research question is answered: Does performing asleep thalamic DBS provide an equal reduction in tremor compared to awake thalamic DBS, measured by the Essential Tremor Rating Assessment…
Primary objective: Identify feasibility of basal-ganglia regions as NF targets in PD patients Secondary objective: Document short-term changes in brain resting-state activation
To determine differences in brain activation and networks in alcohol responsive essential tremor versus alcohol resistant essential tremor.
To investigate whether peripheral nerve and muscle ultrasound can be used as reliable diagnostic and monitoring biomarkers of PNS involvement in SCA3. Specifically, we will examine: 1) Whether peripheral nerve and muscle ultrasound are able to…
To evaluate the effect of the balance assisting device *GyBAR* on balance capacity during standing and gait tasks in people with pure degenerative ataxia.
Primary Objectives• Characterize day-to-day, within-day, intra-individual and inter-individual variability of GCase activity in healthy participants and patients with Parkinson*s disease with a GBA1 mutation.Secondary Objectives• Assess variability…