34 results
Research questions:1. Does music therapy improve the expressive and communicative skills of patients with HD due to (specific) music therapy treatment? 2. Does music therapy change problem behavior of patients with HD?
The aim of this study is to assess whether a structured medication review in primary care improves medication adherence and leads to positive patient outcomes in patients with PD. The expectation is that the results of this study might be used to…
Primary Study Objective: The primary objective of this study is to assess the efficacy of laquinimod 0.5 mg and 1.0 mg qd in patients with HD after 12 months of treatment using the UHDRS-TMS.Secondary Study Objectives:• To assess the effect of…
Part 1: The primary objective is to investigate if the RNFL-ac in PD patients differs significantly from the RNFL-ac in healthy controls.Secondary Objectives are:1) to investigate if the RNFL-ac can be used to differentiate PD patients from healthy…
Objectives: To evaluate whether aerobic exercise leads to clinically relevant improvements in 1) motor and 2) non-motor symptoms as well as quality of life and physical fitness.
The specific aims for this study are to identify whether a structured exercise programme:a. is feasible for people with HD, in terms of adherence, process and safetyb. improves physical fitness in people with HDc. improves physical function and…
Primary Objective is to determine whether (A) patients with dystonia(plus) syndromes exhibit more psychiatric symptoms compared to a healthy control group and (B) whether dystonia patients show an altered serotonin metabolism (serotonin transporter…
The current proposal aims at investigating the effect of a multidisciplinary non-verbal intervention on the awareness and modulation of WRA to improve self-efficacy, mobility, mood, and quality of life as compared to usual care.
To investigate the differences in driving performance and safety between CD patients and healthy controls in a driving simulator. To compare the subjective evaluation of the difficulty of various aspects of the driving task driving in CD patients…
The primary objective of the trial is to investigate the efficacy of apomorphine subcutaneous infusion compared to placebo in PD patients with motor fluctuations not well controlled on medical treatment. The secondary objective is to investigate the…
The main objective of this study is to characterize the features and the extent of extracerebellar structural pathology in SCA3 and SCA6 patients. Secondary objectives are:- To explore the sensitivity of DWI and other imaging modalities in detecting…
This research project exists out of two research questions:Firstly we will determine which gait parameters are associated with fall risk. Secondly develop a novel fall prevention program based on the associated fall risk gait parameters. To…
The primary objective of this study is to determine if and how specific characteristics of visual information influence the motor control strategy adopted by healthy subjects during a visuomotor tracking task. Changes in wrist joint impedance (i.e…
The project aim is to optimize existing EEG methods for recording and analyzing EEG data acquired during walking in combination with advanced VR methods for the investigation and rehabilitation of gait and balance impairments. The project aims to…
We hypothesize that PD patients with dopa-responsive and dopa-resistant tremor have different tremor-related brain activity, different inter-regional functional connectivity, and different GABA-ergic tone in the thalamus. Furthermore, we expect that…
The main objective of this study is to evaluate whether the PowerGlove is a valid instrument that can be used for the assessment of hand motor symptoms in patients with Parkinson*s disease. Sensitivity, specificity, intra-examiner reliability and…
The aim of the study is to investigate the differences in multi-joint coordination between healthy young and healthy elderly. Secondly, we want to study adaptation of ankle and hip strategy with the application of whole-body force fields and…
1. We will recruit 6 probands who experience cerebellar movement disorders with spinocerebellar ataxia features such as uncoordinated movement (i.e. asthenia, asynergy, delayed reaction time and dyschronometria) in limbs and organs such as the eyes…
Our objective is to perturb neural activity in the parietal-occipital cortex in PD patients (and age-matched control subjects) to determine if the activity contributes to better visually-guided behaviour, but at the same time, to diminished…
The main goal of this study is to investigate the side effects of deep brain stimulation in Parkinson's disease. An important aspect of these side effects is the reward-oriented behavior. For this reason, patients will be administered…