27 results
1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…
(1) To determine the frequency of antibody-mediated encephalopathy in children with seizure-related or (sub)acute onset neuropsychiatric disorders. (2) To identify the target auto-antigens of selected seizure-related and (sub)acute onset…
(1) To determine frequency of antibody-mediated encephalopathy in adults with new-onset epilepsy/status epilepticus or chronic epilepsy. (2) To assess outcome of antibody-mediated encephalopathy in adults with epilepsy, and identify markers for good…
To assess in vivo microglial activation (as a validated marker of neuroinflammation) using PET-CT and associated neuropsychological characteristics in patients recovered from sepsis associated delirium.
To evaluate the incidence, causes and characteristics of meningitis and/or encephalitis in patients of all ages:1. To determine the causes of meningitis and/or encephalitis in children and adults2. To evaluate the clinical signs and symptoms and CSF…
The objectives of the complete NIMBL study are as follows:Objective 1. Gain insight into the natural history of AGS and RVCL* Create a registry of paediatric and adult AGS and RVCL patients, and develop a network of clinicians caring for these…
To evaluate neurologic- and cognitive disorders, neuroimaging and ophthalmological alterations in perinatally HIV-infected children in comparison to matched (with respect to age, sex, race, home environment and socio-economic status) healthy…
to investigate functional characteristics of immune cells from MS patients, including migratory capacity, inflammasome activity and Breg cell function and compare these to healthy control subjects 2) to assess possible differences with regard to the…
The primary objective of this study is to determine the prevalence and degree of cognitive complaints and impairment of patients with MS. Secondly we want to determine the relationship between age, gender, clinical type of MS and disease progression…
1) To investigate the VDR levels in different MS associated T cell subsets2) to compare the VDR levels in the different T cell subsets between MS patients and age and gender matched healthy volunteers
The purpose of this study is to investigate the association between T cell compartment composition and vitamin D status in MS patients, with particular interest for regulatory T cell functionality.
1. Characterize the interplay between host factors and bacterial factors and the specific activation of inflammatory pathways.2. Evaluate the expression of identified risk genes after activation of inflammatory pathways in host immune mediating…
Our aims are to analyse whether there is a specific HLA allele or allelic combination associated with susceptibility to LGI1 encephalitis, and to perform a pilot study with HLA subtyping in patients with encephalitis due to antibodies to Caspr2,…
To increase insight in cerebral injury of perinatally HIV-infected children by comparing neurological, ophtalmological and neurocognitive outcomes to those of matched controls (with respect to age, sex, ethnic background, home environment and socio-…
The primary objectives of the NO GBS study part 1 are to: - determine the clinical characteristics and outcome, and the prevalence of risk factors used by Dutch guidelines for risk assessment in GBS and E. coli meningitis and sepsis cases aged 0-3…
In this observational cohort study we will determine the prevalence and genetic profile of colonizing GBS isolates in pregnant women in the Netherlands. We will collect serum from pregnant women and their newborns to determine specific IgG…
Primairy objective:- Identify causes of secondary deterioration or failure to improve after viral encephalitis by studying activation of the immune system and production of autoantibodies.Secondary Objectives are to:- Determine if the delayed…
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…
In this research proposal, we aim to develop chemical reporter molecules to study neutrophil activity and NET formation in real-time. We will systematically study the effect of brain-associated amyloid fibrils on NET formation and investigate the…
The aim of this study is to quantify neuroinflammation and whole-body inflammation with [18F]DPA-714 PET scans in post-COVID-19 patients and relate it to cognitive, psychiatric and post-infectious fatigue symptoms.