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Perioperative Transfusion Study (PETS): does a liberal transfusion protocol improve outcome in high-risk cardiovascular patients undergoing non-cardiac surgery?

The primary objective of this study is to assess whether a liberal (6.5 mmol/l) transfusion strategy compared to a restrictive (6.0 mmol/l) transfusion strategy lowers the incidence of major adverse cardiac events (MACE). MACE is defined as a…

Offloading the diabetic foot: a direct comparison of the total contact cast, bivalved total contact cast and cast shoe

To assess the efficacy of a TCC, a BTCC and a cast shoe with similar plantar soles on offloading the previous ulcer location in people with DM and peripheral neuropathy.

Healthy Ageing Through Internet Counselling in the Elderly

To investigate whether an interactive internet-based intervention strategy targeting vascular and lifestyle-related risk factors can lead to improvement of cardiovascular risk profile and prevention of cardiovascular disease and whether this in turn…

Reactive foot placement in balance control during standing and walking in healthy young adults and stroke survivors.

The goal of the research is to apply balance perturbations during standing and walking, and capture the resulting stepping responses. These data will be used to develop and verify predictive models of foot placement. Such models might eventually be…

Stenting of symptomatic vertebral artery stenosis. A randomised safety and feasibility study

The primary aim of the proposed study is to assess whether stenting for symptomatic vertebral artery stenosis >= 50% is feasible and safe. A secondary aim is to assess the rate of new vascular events in the territory of the vertebrobasilar…

Evaluation of Secondary Prevention of Stroke Study in the Outpatient Clinic

The main objective of this study is to determine if the SPC has added benefits in optimising risk factors to prevent recurrent stroke, as compared with secondary prevention performed by the GP.

Cost-effectiveness of an active withdrawal of medication policy versus usual care in patients currently treated for hypertension and/or hypercholesterolemia: a cluster-randomised controlled non-inferiority trial in general practice

The general aim of this project is to evaluate the effectiveness, safety and costs of a medication withdrawal policy compared to usual care in general practice in patients who are currently treated for hypertension and/or hypercholesterolemia, but…

Cost-effectiveness of balancing stroke and bleeding risk using CHA2DS2-VASc in primary care patients with Atrial Fibrillation: a management study. CAFe

The objective of this study is to determine the effectiveness of the CHA2DS2-VASc prediction model as directive for the preventive management of AF patients in the first line.

The effect of cervical spinal cord stimulation on the cerebral blood flow

Effect of SCS on CBF

PRognostic hEModynamIc profiling in the acUte ill eMergency department patient: PREMIUM registry

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LIMIT: Lowering the Incidence of vascular complications with Metformin in patients with Impaired glucose tolerance and a recent TIA or minor ischemic stroke: a phase 2, randomized, controlled trial

To examine the safety, tolerability, and effect on glucose metabolism of metformin treatment in non-diabetic patients with TIA or minor ischemic stroke and impaired glucose tolerance.

CRYptogenic STroke And underlying AF (CRYSTAL AF )

PRIMARY OBJECTIVETo evaluate the time to first documented event of atrial fibrillation by 6 months continuous rhythm monitoring versus Standard of Care treatment in patients with a recent cryptogenic stroke or TIA without documented history of…

The evaluation of a group therapy for patients with depressive symptoms after stroke - a pilot study

The objective of the study is to investigate the effect of the *Coping with depressive symptoms after stroke* course on depressive symptoms and quality of life in a waiting list controlled study.

CONVINCE (COlchicine for preventioN of Vascular Inflammation in Non-CardioEmbolic stroke) - a randomised clinical trial of low-dose colchicine for secondary prevention after stroke.

Primary objectiveTo investigate the efficacy of low dose colchicine (0.5mg/day) plus usual care (antiplatelet, lipid-lowering, antihypertensive treatment, and appropriate lifestyle advice) compared with usual care alone to prevent non-fatal…

Continuous glucose monitoring in acute ischemic stroke:
a prospective study of the feasibility of continuous glucose monitoring and evolution of glucose in acute ischemic stroke patients suitable for endovascular treatment

We aim to assess the feasibility of continuous glucose monitoring with CGM in patients with acute ischemic stroke who are eligible for endovascular treatment. In addition, we will assess the evolution of glucose levels in these patients.

PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. A randomised, open, phase III, clinical trial with blinded outcome assessment

Primary objectiveTo assess whether prevention of aspiration, infections, and fever with metoclopramide, ceftriaxone, paracetamol, or any combination of these in the first 4 days after stroke onset improves functional outcome at 90 days in elderly…

Insight into the prevalence of unruptured intracranial aneurysms in a targeted risk-factor population: towards targeted screening

Primary objective:- Determine the number of unruptured IAs in smoking women aged 50-60 years in the Dutch population in a cohort of 55 participants. Secondary objectives:- Evaluate the possible changes in quality of life associated with a screening…

Prospective randomized multi-center controlled clinical investigation comparing PFO outcomes of the Occlutech Flex II PFO Occluder to standard of care PFO occlusion.

The purpose of this clinical study is the assessment of the safety and effectiveness of the Flex II PFO Occluder in the treatment of subjects 18 years of age or older who have had a cryptogenic stroke due to a presumed paradoxical embolism as…

Apixaban versus antiplatelet drugs or no antithrombotic drugs after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation. A randomised phase II clinical trial.

Primary Objective: to obtain reliable estimates of the rates of vascular death and non-fatal stroke in patients with atrial fibrillation and a recent anticoagulation-associated ICH who are treated with apixaban versus those who are treated with APDs…

The dynamic effects of hypertension on the brain and its vessels

Our research aim is fourfold:1) We aim to assess the effect of hypertension on functional and structural markers of the brain using 3 tesla (T) and 7T MRI in patients who are temporary drug naïve and will be switched-on to medication as part of…