376 results
The primary objective is to evaluate whether the concentration of six biomarkers (proteins) in SDH are related to the time of incidence of TBI. The secondary objective is to evaluate whether the fractions of the Hb-derivatives in SDH are related to…
Primary objective:To determine BBB integrity and the interplay with microvessel function including PVS and CVR response to CO2 breathing challenge in sporadic and monogenic presentations of human SVDs.Secondary objective:To determine the…
The primary objective is generation of functional neuronal networks from induced pluripotent stem cells (iPSCs) derived from patients with ischemic stroke. The secondary objectives are to measure neuronal network responses to simulated cerebral…
Primary objective: Determine for different control algorithms and robotic modules whether the algorithm and/or robotic module is effective in providing the patient with the required support and measure bringing about the desired changes in the…
The primary objective of this research programme is to develop a new functional architecture of the visual brain based on two concepts: the methodology to establish necessity and the theoretical framework of cortical networks. In addition, this…
The main objective of this study is to explore the accuracy of sCTA and ceMRA compared to DSA in the diagnosis of complete aneurysm occlusion in patients treated with a FD stent. In addition, we will look at accuracy of sCTA and ceMRA in…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with symptomatic SVDs, relative to controlsSecondary Objective(s): To establish how microvascular function relates to:• parenchymal lesion…
Primary objective: To assess the effect of transdermal GTN, started within 3 hours of symptom onset in the prehospital setting, on functional outcome at 90 days in patients with acute ischaemic stroke or intracerebral haemorrhage.Secondary…
The primary objective of this randomized controlled trial is to determine whether decompressive surgery and best medical treatment in patients with spontaneous ICH will improve outcome compared to best medical treatment only. Secondary objectives…
HypothesisWe hypothesize that a CTA of the heart and entire aortic arch, performed in the acute phase (defined as within window for reperfusion therapy through thrombolysis or thrombectomy) in patients with acute ischemic stroke, is superior to…
To explore the effect of single versus repeated preconditioning on circulating blood factors (i.e. metabolomics analysis) as a likely mechanism in patients with cSVD. Secondly, we explore whether the effects of single versus repeated preconditioning…
In oral FXa inhibitor-treated patients with acute intracranial bleeding, the objectives of this study are as follows:Primary Efficacy Objective:• To evaluate the effect of andexanet versus usual care on the rate of effective hemostasis.Secondary…
Our main objective is to develop and validate body fluid biomarkers that detect CAA in Alzheimer*s Disease patients during life.
Delayed cerebral ischemia (DCI) is an important cause of death and dependence after SAH. Vasospasm plays an important role in the pathogenesis of DCI, because many patients have constricted arteries during the period of DCI, but vasospasm is not a…
The objective of the study is to determine whether the HCHWA-D gene mutation affects the proteolysis of AßPP with regard to the ratio of the diverse Aß species produced from AßPP.
Primary aim: to investigate the possible existence of *transient* or non-progressive non-atherosclerotic arteriopathy as a cause of AIS in young adults, and to describe the course of young adulthood unilateral intracranial arterial disease.Secondary…
Primary objective:• To demonstrate that the DTAS triage workflow involving CBCT results in superior patient outcome in ischemic stroke patients with confirmed Large Vessel Occlusion (LVO) as compared to the conventional CT/MR triage workflow.…
To assess the effects of anesthetics on local (cerebral) microvascular parameters in craniotomy patients. Secondary objective: To assess the effects of anesthetics on systemic (sublingual) microvascular parameters in craniotomy patients.
Objectives:The main objective will be to assess whether treatment with nVNS, LXB or both interventions will increase the clearance of Aβ from the brain, compared to pre-treatment, in patients with CAA. Second objective is to study whether CAA…
a) Determine whether acute cardiac CT has a higher probability of diagnosing LA thrombi compared to TEE or repeated cardiac CT in the subacute phase of ischemic stroke by assessing the rate at which LA thrombi dissolve in the first days after…