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The Impact of Intraoperative Carbon Dioxide Wound Ventilation on Cerebral Microembolic Load during Aortic Arch Surgery : a Prospective Randomized Clinical Trial using Transcranial Doppler Ultrasound

The primary objective of this study is to evaluate the impact of carbon dioxide field flooding on the quantitative intraoperative microembolic load of the brain during aortic arch surgery.A secondary objective is to evaluate any concomitant…

Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial

To determine the effectiveness of more intensive BP lowering provided by a *Triple Pill* strategy on top of standard of care, on the time to first occurrence of recurrent stroke after ICH.

Combined effects of SGLT2 inhibition and GLP-1 receptor agonism on food intake, body weight and central satiety and reward circuits in obese T2DM patients

Primary objective:To investigate the separate and combined actions of the SGLT2 inhibitor dapagliflozin and GLP-1 receptor agonist exenatide on activity in central reward and satiety circuits in response to food related stimuli in obese patients…

Predicting the effect of transcranial direct current stimulation on brain excitability

Primary Objective: To verify the main effect of TDCS on brain excitability and the interaction effects of BDNF genotype and APLM latency on this main effect. Secondary Objectives: Compare different prediction models for the main effect of TDCS in a…