27 results
This protocol is the next step in development of a reproducible technique for the quantification of CBF using simultaneous ultrasound at the internal carotid artery. We hypothesize that simultaneous measurement of the contrast signal in the internal…
To ascertain the hypothesis that T-cell inflammation in the vascular wall of an unruptured intracranial aneurysm can be accurately detected with 18F-IL2 PET (proof-of-concept).
PRIMARY OBJECTIVETo evaluate the safety and tolerability of single ascending, intravenous doses of ACT017 administered as a 6-hour intravenous (i.v.) infusionSECONDARY OBJECTIVES* To evaluate the pharmacokinetics of single ascending, intravenous…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.
Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…
Primary Objective: To establish the effect of asymmetrical guidance provided by the Lokomat exoskeleton on levels of muscle activity in persons with post stroke hemiparesis. Secondary Objective(s): (i) To establish if the abovementioned effects (see…
Objective: To evaluate the adherence of patient*s use of OS.
To investigate if antiplatelet therapy consisting of ticagrelor plus ASA is superior to clopidogrel plus ASA in preventing ischaemic brain lesions occurring as a result of CAS assessed on magnetic resonance imaging (MRI).
To assess the effect of IAT compared with best medical treatment in patients with AIS caused by an intracranial large vessel occlusion of the anterior circulation, who have moderate to good collaterals and who can be treated between 6 and 24 hours…
To determine the effectiveness of more intensive BP lowering provided by a *Triple Pill* strategy on top of standard of care, on the time to first occurrence of recurrent stroke after ICH.
Objective 1)To determine the cost-effectiveness of screening for and preventive treatment of UIAs in persons with FDRs with UIAs. We will therefore assess the prevalence of UIA in persons with >=1 FDR with an UIA, the costs of the screening,…
To assess the effect of acetylsalicylic acid (ASA) and unfractionated heparin, alone, or in combination, in patients with AIS, who undergo IAT for a confirmed intracranial anterior circulation occlusion.
The aim of this study is to assess the long-term outcomes (up to 36 months) and costs of stroke after EVT treatment, including direct EVT and IVT followed by EVT.
Primary objective:To test the hypothesis that the calcium channel blocker amlodipine has a superior beneficial effect on cerebrovascular reactivity in patients with symptomatic SVDs when compared to either the Angiotensin II type 1 (AT1) receptor…
Primary objective:To investigate the separate and combined actions of the SGLT2 inhibitor dapagliflozin and GLP-1 receptor agonist exenatide on activity in central reward and satiety circuits in response to food related stimuli in obese patients…
1) To identify clinical and imaging predictors of recurrent stroke; 2) To improve early detection of small volume stroke with admission computed tomography perfusion (CTP) in patients with suspected acute ischemic stroke with small volume stroke or…
Primary objective:To determine BBB integrity and the interplay with microvessel function including PVS and CVR response to CO2 breathing challenge in sporadic and monogenic presentations of human SVDs.Secondary objective:To determine the…
Primary objective: Determine for different control algorithms and robotic modules whether the algorithm and/or robotic module is effective in providing the patient with the required support and measure bringing about the desired changes in the…
Primary objective: To assess the effect of transdermal GTN, started within 3 hours of symptom onset in the prehospital setting, on functional outcome at 90 days in patients with acute ischaemic stroke or intracerebral haemorrhage.Secondary…
The main objective of this effectiveness study is to test if intensive control (SBP *120 mmHg) decreases cerebral blood flow velocity compared to conventional targets (SBP<140-150 mmHg) in patients with CSVD and hypertension. Secondary…