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Long-term neurodevelopmental outcome after perinatal arterial ischemic stroke

The main goal of this study is to determine motor, cognitive, behavioral, executive, and language functioning of children with PAIS at school age. Furthermore, we will analyze the effect of PAIS on brain growth, development, and connectivity using…

Immediate carotid artery stenting during endovascular treatment of acute ischemic stroke versus a deferred treatment of carotid artery stenosis. A randomized multicenter clinical trial in patients with acute ischemic stroke and carotid artery stenosis undergoing endovascular treatment.

The primary objective of this trial is to assess the efficacy of immediate CAS among patients with acute ischemic stroke treated with EVT and a severe ipsilateral proximal carotid artery stenosis (>50%) or occlusion and compare this with the…

A randomized, placebo-controlled, double blind trial to study the effects of Etidronate on ectopic CALCIfication in FAhr*s Disease or syndrome.

This study has been transitioned to CTIS with ID 2024-512300-19-00 check the CTIS register for the current data. The objective is to determine whether etidronate can halt or attenuate disease progression in patients with Fahr*s disease or syndrome.

Evaluating the value of neuromechanical assessment in spasticity treatment

1. Evaluate the relation between pretreatment muscle weaknesses, spasticity, abnormal synergies, and changes in viscoelastic joint properties on the one hand, and changes in upper extremity spasticity following treatment on the other hand in…

Prospective randomized multi-center controlled clinical investigation comparing PFO outcomes of the Occlutech Flex II PFO Occluder to standard of care PFO occlusion.

The purpose of this clinical study is the assessment of the safety and effectiveness of the Flex II PFO Occluder in the treatment of subjects 18 years of age or older who have had a cryptogenic stroke due to a presumed paradoxical embolism as…

Prehospital triage of patients with a suspected acute stroke

The overall objective of the PRESTO-2 study is to evaluate the implementation of the Stroke Triage App, a decision support tool for individualized prehospital triage of patients with potential stroke.The specific objectives are the following:1)…

Multicentre Randomised trial of Ghrelin in anterior circulation ischemic stroke treated with endovascular thrombectomy. A randomized phase 2 trial

The primary objective of this study is to assess the effect of ghrelin on the severity of the neurological deficit at seven days after symptom onset in patients with acute ischemic stroke caused by large vessel occlusion of the anterior circulation…

Mind the Heart 2: Detecting cardiac thrombi in acute ischemic stroke on cardiac CT versus transoesophageal echocardiography

a) Determine whether acute cardiac CT has a higher probability of diagnosing LA thrombi compared to TEE or repeated cardiac CT in the subacute phase of ischemic stroke by assessing the rate at which LA thrombi dissolve in the first days after…

EnDovascular therapy plus best medical treatment (BMT) versus BMT alone for MedIum VeSsel Occlusion sTroke - a prAgmatic, international, multicentre, randomized triaL (DISTAL)

The primary objective of this randomized trial is to determine whether patients experiencing an AIS due to an isolated medium vessel occlusion have superior functional outcome (measured with the mRS at 90 days) when treated with EVT plus BMT…