89 results
The primary aim of the study is to investigate the feasibility of a RCT study on effectivity and workingmechanisms of HRT in children with CP. The Doel van deze studie is ten eerste de feasiblity onderzoeken van een toekomstige RCT study over het…
Objective #1: Implement clinical platform. We see the need to implement a clinical platform for two purposes. First, we want to design a biomarker profile of perinatal brain damage in human newborns (see above). Thus, we have established a…
The aims of the study are 1) to upgrade an existing GA protocol based on inertial system(developed at the INAIL Prostheses Centre in collaboration with the University of Bologna) in terms offinding out which calibration procedures result suitable to…
The objective of this research is to find out to what extent a correlation exists between axonal misrouting, the extent of the injury and the associated functional recovery.
To optimize the 3D ultrasound reconstruction and dynamometer as a clinical tool for measurement of morphological and mechanical muscle properties, and to compare the m .gastrocnemius medialis of healthy children to the m .gastrocnemius medialis of…
To investigate if rhEPO has a positive effect on MRI/MRA parameters compared to infants with stroke without rhEPO collected from historical data.To investigate if rhEPO (3 dosages of 1000IU/kg/day) for perinatal stroke has no negative side-effects…
This project aims to develop an evidence based effective and "safe" dosing regimen for commonly used life saving medicationsused in the treatment of asphyxiated, critically ill newborns, undergoing therapeutic hypothermia.To this aim the…
Aim of this project is to diagnose hearing impairment, and underlying disorders in speech perception and production, and to develop and implement adequate intervention techniques, which are subsequently evaluated. The ultimate goal is to prevent…
- To gather long-term data on the safety and tolerability of idebenone inFriedreich*s Ataxia- To explore the effect of idebenone after longer term administration onneurological symptoms and signs as assessed by the InternationalCooperative Ataxia…
Objective: to determine whether botulinum toxin A (btA) injections, intensive bimanual skill training, or a combination of both leads to more and better use of the affected arm in hemiparetic children in play, leisure time, school and personal care.
To investigate the effect of Botulinum toxin treatment on the activity level of people with spastic hemiparese after stroke.
Zonisamide (Zonegran) and sodium valproate (Epilim) are both medicines approved for the treatment of epilepsy. This study is intended to investigate to what extent zonisamide can affect your memory and concentration in comparison with sodium…
Objective is to study the effect of Targeted Training Therapy on balance control in children with Cerebral Palsy.
1. The development of a standardized screeningsinstrument to evaluate the language comprehension of severly handicapped children with movement disorders and who cannot speak, as a result of white matter damage.2.To evaluate the difference between…
To determine to what extent dynamic spasticity can be recognized and quantified in the gait pattern of children with spastic CP and to develop a meaningful and (clinically) applicable measure of dynamic spasticity
The main goal of the VUmc part of the study is to acquire sets of data related to Neurological and Neuromuscular Diseases; in order to build a paediatric digital repository and to develop biophysical modelling and probabilistic modelling.
1- to describe the presence and severity of hemiplegic CP on the basis of neonatal MRI findings and correlate the involvement of different structures (basal ganglia, posterior limb of the internal capsule and hemisphere) with the size of the lesion2…
To examine the intra-rater reliability and validity of the paediatric DDA.
To assess in moderate preterm infants:1) The prevalence and characteristics of brain injury; 2) The relation between perinatal factors and brain injury;3) The validity of cUS for detection of brain injury as compared to MRI (considered the golden…
The primary objectives of the study are to investigate the vitamin D status of Dutch children with motor disabilities attending a special needs school and to associate Vit D status to the level of physical functioning, other potential risk factors…