38 results
Project A- To find biomarkers of traumatic brain damage and to find specific biomarkers of traumatic axonal injury.Project BTo investigate the value of MRI (T1, T2*, FLAIR, SWI and DTI) in detecting traumatic axonal lesions and predicting outcome.…
The aim of the proposed research is twofold: 1) To investigate whether TMS can help guide individual AED treatment to improve response. a. in people with first seizures b. in people who (temporarely) want to lower or stop medication2) To investigate…
Our goal is to build a faster SPES algorithm for execution and analysis which produces the same information as the current, classic SPES protocol. This faster protocol is obtained by predicting optimal stimulus parameters and settings in a computer…
1. To test the performance of the wearable SDD (Nightwatch) prospectively and the remote SDDs (video and audio) retrospectively in a family home setting. 2. To explore the feasibility of the Nightwatch
The primary objective of this study is to evaluate differences in motor evoked potential (MEP) and TMS evoked potential (TEP) to paired pulse TMS between epilepsy patients and healthy controls. Secondary objectives are 1) To evaluate differences in…
To demonstrate that novel MEG sensors can be used successfully in clinical practice, and to demonstrate their effectiveness as a powerful diagnostic tool in epilepsy.
1. Increase detection and localization of epileptogenic lesions using non-invasive TMS stimulation of suspect region's2. Decrease invasiveness and/or improve the accuracy of the presurgical evaluation by comprehensive noninvasive testing of…
Objective: The primary objective of this pilot project is to investigate the early course of motor development in children with DS. Secondary objectives are to investigate the relation between type of SCN1A mutation and developmental profile and to…
We started to evaluated the feasibility of subcutaneous EEG electrodes in epilepsy patients undergoing VNS therapy in a pilot study. This part is currently finished.Currenrly, we are extending the cohort and aim to identify biomarkers to predict…
Primary objective of this clinical investigation is to evaluate superiority of the signal quality of SOFT ECoG flexible high-density electrode grids compared to regular high-density electrode grids, routinely used at the UMC Utrecht. The signal…
To investigate the trajectories of cognitive and adaptive functioning in adults with epilepsy and ID. In doing so we are looking for clinical determinants of cognitive and adaptive decline. Furthermore, the association between decline and serum…
The primary aim of this clinical trial and healthcare evaluation (in Dutch: Zorgevaluatie) is to compare the diagnostic value of two diagnostic EEG strategies (repeated EEG with and without prior sleep deprivation) frequently applied in current…
To evaluate the effect of AI-assisted interpretation of ambulatory EEG recordings compared to standard care (starting with a routine EEG) on the time to diagnose epilepsy (measured as the time in weeks between initial referral for an EEG and the…
The research objective is to obtain a more targeted RFTC treatment strategy by gaining more insight into the organization of epilepsy networks. We will study how RFTC affects large-scale brain networks in focal epilepsy and whether these network…
To identify neuronal activation patterns in response to cognitive stimuli
To characterize glioma and epileptogenic tissue with 7T metabolic MRI, and validate their metabolic imaging characteristics with histopathological measures.
The objective of this study is to develop an algorithm for the detection of nightly tonic seizures. The to be developed algorithm has to be designed in a way that it can be embedded in an ultra low-powert miniaturized device.The clinical usefulness…
Main Objectives: To assess the effect of perampanel on cortical excitability in people with medically refractory epilepsy.Secondary Objectives; To investigate the predictive value of TMS-EMG/EEG for long-term seizure control after starting…