12 results
This study has been transitioned to CTIS with ID 2023-506543-41-00 check the CTIS register for the current data. This Extension study will evaluate the effectiveness and safety of ocrelizumab in MS patients who were previously enrolled in a Roche…
The primary objective of the study is to investigate changes in white matter structural integrity in patients with relapsing remitting multiple sclerosis (MS) after treatment with dimethyl fumarate and its relation to physical and cognitive…
To evaluate safety, tolerability pharmacokinetic profile; to explore pharmacodynamics; to evaluate major effects of Guanabenz on quantitative MRI and clinical parameters in pediatric patients with VWM; explore biomarkers in blood and cerebrospinal…
synopsis:Primary:• To assess the health related quality of life (HRQoL) through the MSQoL-54 scale in highly-active relapsing multiple sclerosis (RMS) subjects treated with Mavenclad® for 2 years (24 months)Secondary:• To assess treatment…
Primary Objective: To develop a protocol for NMES for dysphagia to determine optimal electrode placement and stimulation parameters in MS patients.Secondary Objective: To determine variability in location, morphology, and type of motor dysfunctions…
This study has been transitioned to CTIS with ID 2023-506429-13-00 check the CTIS register for the current data. This study will evaluate the effectiveness and safety of ocrelizumab in PMS patients.
The main objective of this pilot study is to explore the changes in physical fitness in patients with MS or SCI who participate in this training program. Secondary, we will explore the changes in walking efficiency, fatigue, quality of life, and the…
to develop and explore measuring methods using conventional smartphones to quantify fatigue, disease activity, and short term and long progression in a day-to-day setting in patients with MS. Key research questions: - Are the NeuroKeys and MS Sherpa…
The aim of this pilot study is to investigate the feasibility and to gain preliminary information on the effectiveness of a cognitive rehabilitation program in patients with (severe) progressive MS, i.e. a speed of processing training (SPT).…
The aim of the present study is to examine whether MS patients report a significant higher amount of behavioural problems compared to the normal population and another patient group diagnosed with a non CNS-involved chronic disease (patients with…
To assess PK of MPhs and MP.
We and others have clearly demonstrated in animal models of MS that the [11C]MeDAS PET signal correlates well with myelin density and therefore can be used to monitor myelin loss and repair in vivo. These promising preclinical results warrant…