46 results
Primary objective is to assess in vivo neuroinflammation quantitatively in patients with sepsis. Secondary objective is to study whether differences in in vivo neuroinflammation are related to long term cognitive outcomes.
The aim of the present study is to investigate the reproducibility of upper extremity strength measurements in children with CP. The following strength measurement instruments will be studied: Hand Held Dynamometry (HHD), pinch- and grip strength…
Our aims are to identify the clusters of impairments in cognition, behavior, quality of life, and fatigue in children after anti-NMDAR encephalitis, to identify risk factors affecting functional outcome and to assess the progression or remission…
Primary Objective: to determine the strength of the dynamic autoregulation of patients after cardiac arrest during the post cardiac arrest syndrome. Secondary Objectives:to observe the natural course of the autoregulation during the first year after…
Primary objective is to quantitatively assess differences in in vivo neuroinflammation in patients before and after coronary artery bypass grafting (CABG) surgery. Secondary objective is to study whether diffferences in in vivo neuroinflammation are…
The primary objective of this study is to evaluate the short term safety and tolerability, and pharmacokinetic properties of 2-IB when administered to adult patients after OHCA. Secondary objectives include safety and efficacy parameters at 30 days…
The main objective of this exploratory study it to determine the effectiveness of a 5-week functional gait training on the C-mill to improve gait adaptability in children and adolescents with CP. t The intervention will also be evaluated on activity…
This protocol is a follow-up of a previously submitted protocol (Evaluation of [18F]AV-1451 kinetic modelling in patients with Alzheimer*s Disease and healthy controls, protocol nr. 2014.519), in which the optimal (simplified) kinetic model for [18F…
To estimate the effect of medical treatment of electro-encephalographic status epilepticus on neurological outcome of patients with postanoxic encephalopathy after cardiac arrest
In this study, we aim to improve survival to hospital discharge and costs/QALY in young patients with OHCA by decreasing the time in cardiac arrest by initiating ECPR on scene.
1. To estimate the additional value of early MRI monitoring for the prediction of neurological outcome of comatose patients after cardiac arrest. 2. To gain insight in the pathophysiology of PAE by functional MRI measures and by associating MRI…
To 1) clinically validate the novel PET-tracer [18F]AV1451 for tau pathology as a diagnostic and prognostic marker in tauopathies, 2) to examine the (change in) (regional) binding of [18F]AV1451 across tauopathies, and the relationships between (…
1A) To implement a screening-protocol for HIV related co-morbidities and their risk factors, based on multidisciplinary expert consultation, in a large HIV outpatient clinic and among an HIV-uninfected control group.1B) To assess the prevalence and…
This study (AMYPAD Diagnostic and Patient Management Study) will determine in a real-life clinical setting for whom diagnostic amyloid PET imaging is appropriate, when this is best performed, and how the resulting information is influencing…
This study has the purpose to assess the pharmacokinetic (the science determining the fate of substances administered to the human body), safety and efficacy of brivaracetam (the study drug) in neonates who have seizures that are not adequately…
The aim of this study is to assess prospectively the critical period prior to the development of ACLF (1), to uncover mechanistic and pathophysiological processes associated with the development and clinical course of ACLF (2) and to identify the…
The primary objective of the MANTA-study is to investigate MEG-based network topology and 'activity dependent degeneration' as mechanisms in the stereotypical spread of tau pathology (18F-AV1451 retention) in preclinical and clinical…
The primary objective is to measure the dose of cerebral ischemia, as a measure of cerebral hypoperfusion, before, during and after aortic arch surgery. Secondary objectives include parameters that influence the occurrence of cerebral ischemia (…
To determine the potential impact of ball heading in football on brain integrity as assessed by blood biomarkers for neural damage in a real-world setting.
The primary goal of NEwTON is to study the link between repetitive head injury and neurodegeneration, leading to cognitive, psychiatric and behavioral symptoms as found in CTE. We will collect a prospective cohort of patients at high risk of CTE,…