32 results
Primary objective:The following hypothesis will be tested:MuSSAP in infants 4-12 months of age with diagnosed unilateral cerebral damage, is a feasible protocol and results in an enhanced motor development as compared to Intensive Usual Care (Upper…
The goal of the study is to enhance the participation in daily life of children with CP, by increasing their independent use of the upper limb performing daily life activities. By training the task oriented strength in daily life activities…
To assess the safety and feasibility of inducing mild hypothermia prior to reperfusion as a means of reducinginfarct size in subjects suffering from STEMI and improve neurologic outcome in subjects experiencing CA followingthe return of spontaneous…
Primary objective: To evaluate whether there is a difference in all-cause mortality at 180 days or longer with a target temperature management at 33°C compared to a target temperature of 36°C, in patients unconscious after out-of-hospital OHCA.…
Primary Objective: 1) To charaterize microbleeds and microinfarcts at 7T, and compare their prevalence in people with and without diabetes, with or without cognitive impairmentSecondary Objective(s): 2) To assess the relevance of the lesions in the…
Primary Objective: 1) To compare the prevalence en number of microbleeds at 7T between older people with and without DM2, and to relate the lesions to cognitive performanceSecondary Objective(s): 1) To characterize cerebral microinfarcts at 7T and…
Study (population) pharmacokinetics of midazolam, morphine, phenobarbital and lidocaïne during therapeutic hypothermia for adequate dose adjustments.
To determine the effect of the application of burn dressings on the skin of face and neck on the tympanic temperature of healthy volunteers.
The development of an attractive child centred intervention based on the forced use perspective, to study the effects regarding the following question:Is a period of 6 weeks Forced Use of the more affected upper limb (I) for children with Cerebral…
The objective of this study is to develop an effective behavioural treatment for severe drooling. The hypotheses are:1. A behavioural program containing instruction, goal setting, positive practice, self-management techniques, and positive and…
The primary objective of this study is the following:**To evaluate the efficacy of OCR-002 for treatment of an acute hepatic encephalopathyepisode in cirrhotic patients requiring hospitalization**To evaluate the safety and tolerability of OCR-002 in…
Primary objective is to assess in vivo neuroinflammation quantitatively in patients with sepsis. Secondary objective is to study whether differences in in vivo neuroinflammation are related to long term cognitive outcomes.
Primary objective is to quantitatively assess differences in in vivo neuroinflammation in patients before and after coronary artery bypass grafting (CABG) surgery. Secondary objective is to study whether diffferences in in vivo neuroinflammation are…
To estimate the effect of medical treatment of electro-encephalographic status epilepticus on neurological outcome of patients with postanoxic encephalopathy after cardiac arrest
In this study, we aim to improve survival to hospital discharge and costs/QALY in young patients with OHCA by decreasing the time in cardiac arrest by initiating ECPR on scene.
1. To estimate the additional value of early MRI monitoring for the prediction of neurological outcome of comatose patients after cardiac arrest. 2. To gain insight in the pathophysiology of PAE by functional MRI measures and by associating MRI…
Using single-cell transcriptomic and epigenetic profiles of (immune) cells in liquor to investigate which biological and cellular processes are involved in (accelerated) brain aging and cognitive decline after systemic inflammation.
The main objective is to decrease the incidence of delirium in patients receiving surgical treatment of a proximal femur fracture with spinal anesthesia.
The primary goal of NEwTON is to study the link between repetitive head injury and neurodegeneration, leading to cognitive, psychiatric and behavioral symptoms as found in CTE. We will collect a prospective cohort of patients at high risk of CTE,…
Main objective: To assess the efficacy of NBI-921352 as adjunctive therapy on the frequency of countable motor seizuresSecondary Objectives • To evaluate the efficacy of NBI-921352 using the Clinical and Parent/Caregiver Global Impression of Change…