20 results
The general goal of our study is to unravel the anatomical and functional correlates of tinnitus in the human brain using structural and functional magnetic resonance imaging (MRI). We will use a high-field (7 T) MRI scanner and obtain a) detailed…
The primary goal of our study is to map and characterize anatomically and functionally the subcortical structures of the auditory pathway in patients with tinnitus and compare them to controls. To this end, we will use 7 T MRI scanner and measure…
To better understand the relation between anticipation of inhibition and striatal activation. Experiment 1 aims to differentiate between response inhibition and response conflict. Experiment 2 aims to test the effects of subjective expectations of…
First objective is to indicate neurocognitive outcome after mild traumatic brain injury in children. Second objective is to indicate prognostic factors for negative neurocognitive outcome.
1. To quantify the CGRP response after application of red chili pepper extract2. To find the optimal concentration of red chilli homogenate containing capsaicin for this response3. To assess day-to-day variability.
The objective of this study is to acquire a set of images and associated technical information to facilitate regulatory submission of the pulse sequences
The primary study objective is to evaluate the Model 106 VNS Therapy® System cardiac-based seizure detection and Automated Magnet Mode (AMM) stimulation in epilepsy patients. These two new features will be evaluated using continuous observational…
To evaluate the long-term safety and tolerability of Dimebon in AD patients who have successfully completed 26 weeks of blinded treatment in the CONNECTION Study (DIM14) (hereafter referred to as *CONNECTION*).
Also in the group of *healthy prematures*, many children appear to have a deviant sucking pattern op de a terme leeftijd. We want to know the implications of these deviant findings for the later development of the children in question.Only recently…
The primary objective of the SCI and to investigate its effectiveness on locomotor performance, participation and quality of life. The proposed study further aims to assess the time course of effects, not only during the training period, but also…
The aim of this *proof-of-principle* study is to demonstrate that 18F-florbetaben PET can detect amyloid deposition in the myocardium in patients with proven cardiac amyloidosis and excluded amyloid deposition in the myocardium of healthy subjects.…
The primary objective of this study is to assess the performance of selected RMTs against standardised rating scales of ADLs in subjects with preclinical AD, MCI due to AD, and mild-to-moderate AD, and FTD. Secondary objectives are, (a) to evaluate…
The aim of this study is to demonstrate that accurate brain stimulation is possible in anatomical location and timing.
We aim to identify the utility of blood-based biomarkers for AD. Our first objective is to determine percent agreement between plasma biomarkers and clinical diagnosis set in a memory clinic. In summary: testing the agreement between plasma…
Primary objective: describe the longitudinal changes of Aβ38, Aβ40, Aβ42, and Aβ43 concentrations in CSF of patients with CAA, AD, and healthy control cases and estimate the differences in change between those groups.1. Explorative study to…
The goals of the Urimon study is to test the hypothesis that microRNA expression profiles in periodic urine- and blood samples from individuals can be used for the sensitive detection of the onset of disease.
The primary objective of our study is to evaluate sensation (static/moving pressure/touch, hot/cold temperature and pain threshold) of the face in patients with unilateral facial nerve palsy and compare the sensation of the affected side to the non-…
Develop a fast metabolic MRI protocol, based on DMI and 31P-MRSI at ultra-high field MRI, to investigate the Warburg effect and phospholipid metabolism in glioblastoma and to asses metabolic disruption in epilepsy.
To test the hypotheses that EMDR therapy will significantly (1) reduce anxiety in persons with epilepsy-related anxiety symptoms, from pre-treatment to post-treatment, (2) reduce seizure frequency and severity and will (3) improve quality of life…
To assess short-term and long-term safety and tolerability of gantenerumab (RO4909832) given at doses up to 1200mg subcutaneous (SC) every 4 weeks (Q4W).Secondary Objective of the Open-label extension:- To evaluate of the effect of 1200 mg…