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A prospective, multicenter, randomised, double-blind, placebo-controlled,
parallel groups, phase 2/3 study to compare the efficacy and safety of
masitinib versus placebo in the treatment of patients suffering from
Amyotrophic Lateral Sclerosis (ALS)

The purpose of this study is to compare the efficacy and the safety of an experimental drug, masitinib,in combination with riluzole to placebo in combination with riluzole administered during 48 weeks to patients suffering from ALS.You will be…

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Two Year Study to Evaluate the Effect of Subcutaneous RO4909832 on Cognition and Function in Prodromal Alzheimer's Disease with option for an additional two years of treatment

Primary objective:Evaluate the effect of two doses versus placebo gantenerumab subcutaneous injections on the change in Clinical Dementia Rating Sum of Boxes scale (CDR SOB), a global measure of cognition and functional capacitySecondary objectives:…

Seizure detection and automatic magnet mode performance study

The primary study objective is to evaluate the Model 106 VNS Therapy® System cardiac-based seizure detection and Automated Magnet Mode (AMM) stimulation in epilepsy patients. These two new features will be evaluated using continuous observational…

CONNECTION: A Global Phase 3, Double-Blind, Placebo-Controlled Safety and Efficacy Study of Oral Dimebon in Patients with Mild-to-Moderate Alzheimer's Disease

To determine the benefit of Dimebon as compared to placebo on the primary measure of cognition and memory, the Alzheimer*s Disease Assessment Scale * cognitive subscale (ADAS-cog); andTo determine the benefit of Dimebon as compared to placebo on the…

CONNECTION PLUS: An Open-Label Extension of the CONNECTION Protocol (DIM14) Evaluating Oral Dimebon in Patients with Alzheimer*s Disease

To evaluate the long-term safety and tolerability of Dimebon in AD patients who have successfully completed 26 weeks of blinded treatment in the CONNECTION Study (DIM14) (hereafter referred to as *CONNECTION*).

Effects of robot-assisted treadmill training in combination with resistance exercise on locomotor performance and quality of life as well as cardiovascular and neuromuscular properties in patients after stroke and individuals with spinal cord injury.

The primary objective of the SCI and to investigate its effectiveness on locomotor performance, participation and quality of life. The proposed study further aims to assess the time course of effects, not only during the training period, but also…

ASCENDING SINGLE DOSE STUDY OF THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACO-DYNAMICS OF SRA-444 ADMINISTERED ORALLY TO HEALTHY ADULT SUBJECTS

Primary: to assess the safety and tolerability of ascending single oral doses of SRA-444 in healthy adult subjectsSecondary: to obtain preliminary PK and PD profiles of SRA-444 in healthy adult subjects to evaluate the effect of a high-fat meal on…

T-REEX: Phase locked TRanscranial Electrical EXcitation

The aim of this study is to demonstrate that accurate brain stimulation is possible in anatomical location and timing.

A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER BASKET STUDY TO EVALUATE THE EFFICACY, SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SATRALIZUMAB IN PATIENTS WITH ANTI*N METHYL D ASPARTIC ACID RECEPTOR (NMDAR) OR ANTI*LEUCINE RICH GLIOMA INACTIVATED 1 (LGI1) ENCEPHALITIS

This study has been transitioned to CTIS with ID 2023-504226-18-00 check the CTIS register for the current data. This study will evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of satralizumab compared with placebo in each of…

Metabolic MRI in brain cancer and epilepsy

Develop a fast metabolic MRI protocol, based on DMI and 31P-MRSI at ultra-high field MRI, to investigate the Warburg effect and phospholipid metabolism in glioblastoma and to asses metabolic disruption in epilepsy.

*EPILEPSY AND ANXIETY: TARGETING A VICIOUS CYCLE. Effectiveness of EMDR in targeting epilepsy-related anxiety, quality of life and subjective cognitive functioning*

To test the hypotheses that EMDR therapy will significantly (1) reduce anxiety in persons with epilepsy-related anxiety symptoms, from pre-treatment to post-treatment, (2) reduce seizure frequency and severity and will (3) improve quality of life…

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Two Year Study to Evaluate the Effect of Subcutaneous RO4909832 on Cognition and Function in Prodromal Alzheimer's Disease with Option for up to an Additional Two Years of Treatment and up to Three Years of an Open-Label Extension with Active Study Treatment

To assess short-term and long-term safety and tolerability of gantenerumab (RO4909832) given at doses up to 1200mg subcutaneous (SC) every 4 weeks (Q4W).Secondary Objective of the Open-label extension:- To evaluate of the effect of 1200 mg…

Ghrelin treatment of comatose patients after cardiac arrest:
A phase 2 clinical trial to estimate safety and efficacy of ghrelin to promote cerebral recovery

Primary objective: We aim to measure safety and efficacy of intravenous treatment with acyl-ghrelin to promote cerebral recovery in comatose patients after cardiac arrest. Safety will be monitored throughout hospitalization and during follow-up…