23 results
The general goal of our study is to unravel the anatomical and functional correlates of tinnitus in the human brain using structural and functional magnetic resonance imaging (MRI). We will use a high-field (7 T) MRI scanner and obtain a) detailed…
The purpose of this study is to compare the efficacy and the safety of an experimental drug, masitinib,in combination with riluzole to placebo in combination with riluzole administered during 48 weeks to patients suffering from ALS.You will be…
The primary goal of our study is to map and characterize anatomically and functionally the subcortical structures of the auditory pathway in patients with tinnitus and compare them to controls. To this end, we will use 7 T MRI scanner and measure…
Primary objective:Evaluate the effect of two doses versus placebo gantenerumab subcutaneous injections on the change in Clinical Dementia Rating Sum of Boxes scale (CDR SOB), a global measure of cognition and functional capacitySecondary objectives:…
First objective is to indicate neurocognitive outcome after mild traumatic brain injury in children. Second objective is to indicate prognostic factors for negative neurocognitive outcome.
The objective of this study is to acquire a set of images and associated technical information to facilitate regulatory submission of the pulse sequences
The primary study objective is to evaluate the Model 106 VNS Therapy® System cardiac-based seizure detection and Automated Magnet Mode (AMM) stimulation in epilepsy patients. These two new features will be evaluated using continuous observational…
To determine the benefit of Dimebon as compared to placebo on the primary measure of cognition and memory, the Alzheimer*s Disease Assessment Scale * cognitive subscale (ADAS-cog); andTo determine the benefit of Dimebon as compared to placebo on the…
To evaluate the long-term safety and tolerability of Dimebon in AD patients who have successfully completed 26 weeks of blinded treatment in the CONNECTION Study (DIM14) (hereafter referred to as *CONNECTION*).
Also in the group of *healthy prematures*, many children appear to have a deviant sucking pattern op de a terme leeftijd. We want to know the implications of these deviant findings for the later development of the children in question.Only recently…
The primary objective of the SCI and to investigate its effectiveness on locomotor performance, participation and quality of life. The proposed study further aims to assess the time course of effects, not only during the training period, but also…
Primary: to assess the safety and tolerability of ascending single oral doses of SRA-444 in healthy adult subjectsSecondary: to obtain preliminary PK and PD profiles of SRA-444 in healthy adult subjects to evaluate the effect of a high-fat meal on…
The aim of this *proof-of-principle* study is to demonstrate that 18F-florbetaben PET can detect amyloid deposition in the myocardium in patients with proven cardiac amyloidosis and excluded amyloid deposition in the myocardium of healthy subjects.…
The primary objective of this study is to assess the performance of selected RMTs against standardised rating scales of ADLs in subjects with preclinical AD, MCI due to AD, and mild-to-moderate AD, and FTD. Secondary objectives are, (a) to evaluate…
The aim of this study is to demonstrate that accurate brain stimulation is possible in anatomical location and timing.
We aim to identify the utility of blood-based biomarkers for AD. Our first objective is to determine percent agreement between plasma biomarkers and clinical diagnosis set in a memory clinic. In summary: testing the agreement between plasma…
This study has been transitioned to CTIS with ID 2023-504226-18-00 check the CTIS register for the current data. This study will evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of satralizumab compared with placebo in each of…
Primary objective: describe the longitudinal changes of Aβ38, Aβ40, Aβ42, and Aβ43 concentrations in CSF of patients with CAA, AD, and healthy control cases and estimate the differences in change between those groups.1. Explorative study to…
The goals of the Urimon study is to test the hypothesis that microRNA expression profiles in periodic urine- and blood samples from individuals can be used for the sensitive detection of the onset of disease.
Develop a fast metabolic MRI protocol, based on DMI and 31P-MRSI at ultra-high field MRI, to investigate the Warburg effect and phospholipid metabolism in glioblastoma and to asses metabolic disruption in epilepsy.