40 results
We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).
To determine the mechanism of action of propranolol in the prophylactic treatment of migraine.
In 2016, Henssen et al. discuss that orofacial pain may be conducted in a bilateral fashion, inducing activation of both thalami [1]. For this reason, bilateral stimulation of the motor cortex is thought to induce a stronger analgesic effect…
Primary Objective:The primary objective is to compare the pain free rates at 15 minutes following the use of GammaCore® with that of a sham device, for acute treatment of cluster headache attacks.Secondary Objectives:The secondary objectives will…
The focus of this present study will be to better understand the mechanism of ONS in MICCH. The primary objective of this study is to investigate the putative differences in rCBF at 6 months follow-up compared to baseline between responders of ONS…
To find a simple test to explain non-responsiveness to sumatriptan in a proportion of patients with migraine.
to assess the single-dose safety, tolerability and pharmacokinetic profile of (6) individual doses of tonabersat ranging from 160 mg to 480 mg (or to dose-limiting toxicity (DLT)) in healthy subjects under the fasted or fed conditionsto assess the…
The objective of this study is to test the safety of the research study drug, MK-0462 (rizatriptan) and to test the ability of study drug to relieve or reduce migraine for the study population.
The purpose of the study is to investigate how safe the compound USL260 is and how well the compound USL260 is tolerated under fasting and fed conditions. The study will also investigate how quickly and to what extent the compound USL260 is absorbed…
The primary objective in this study is to compare the effectiveness of lateral C1-2 pulsed radiofrequency application (LPRF) in comparison with conventional C3-5 facet denervation (MBRF) in patients with clinically defined cervicogenic headache.
The objective of this study is to test the safety of the research study drug, MK-0462 (rizatriptan) and to test the ability of study drug to relieve or reduce migraine for the study population.
To test whether probiotics, as adjuvant therapy, can reduce incidence and severity of migraine attacks by reducing intestinal permeability.
Primary: To study whether there is a difference in treatment effect between oxygen at flow rates of 7 L/min versus 12 L/min in the acute treatment of cluster headache attacks. Secondary: - Identifying subgroups in which oxygen at flow rates of 7 L/…
The primary objective of this study is to investigate whether differences in patient specific pharmacokinetic properties, both dynamic and absolute, reveal the difference in response to lithium treatment. The pharmacokinetic properties which will be…
Supported by the observation from the Phase I studies in healthy volunteers, doses within a range of 50 to 500 mg are safe and well tolerated. This Phase II trial will be performed to:a. obtain proof of concept of BI 44370 TAb. perform dose finding…
Main objective of this study is to assess the effects of MVD in management of patients with persistent, drug-resistant CH in terms of pain reduction and improvement of quality of life. More specific: to evaluate if MVD can provide adequate pain…
The objective of this pilot study is to test the feasiblity of all procedures of the RCT. The aim of the final study is to investigate the short term and long term effects of manual therapy on the frequency of headache and the use of pain medication…
As a result of the vele symptoms which can appear at these patientengroep several diagnoses to be mostly put because many occupational groups occupy themselves such as dentists, dental surgeons, chiropraktikers, osteopaten and fysiotherapeuten,…
Main objective of this study is to assess the effects of MVD versus RF of the pterygopalatine ganglion in management of patients with persistent, drug-resistant SN in terms of pain reduction and improvement of quality of life.
The purpose of Part A is to investigate how quickly and to what extent Rizatriptan in DFN-10 is absorbed and eliminated from the body (this is called pharmacokinetics). In addition, it will be investigated to what extent DFN-10 is tolerated.In Part…