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Microvascular and Cardiovascular Status of Females with and without Migraine

The primary objective is to determine and compare the microvascular status between middle-aged women with and without migraine. Secondary objectives include a determination of the agreement and reproducibility of two devices which measure the blood…

Triggers and prediction of attacks in migraine: smartphone behaviour and E-diary

The general aim of this study will be to unveil that day-to-day variations in smartphone tappigraphy reflect dynamic changes in brain states that can be linked to the migraine attack cycle and triggers. We will use our self-developed and verified…

Interventional, open-label, fixed-dose multiple administration study to evaluate long-term treatment with eptinezumab in patients with chronic cluster headache

Primary Objective:To evaluate the long-term safety and tolerability of eptinezumab in patients with chronic cluster headache (cCH)Secondary ObjectivesTo evaluate the efficacy of eptinezumab in patients with cCHExploratory ObjectiveTo explore the…

A Phase 3, Multicenter, Open-Label 156-Week Extension Study to Evaluate the Long-Term Safety and Tolerability of Oral Atogepant for the Prevention of Migraine in Participants with Chronic or Episodic Migraine

This study has been transitioned to CTIS with ID 2023-507096-21-00 check the CTIS register for the current data. To evaluate the safety and tolerability of treatment with atogepant 60 mg once daily when administered over 156 weeks for the prevention…

Occipital nerve stimulation: Real-world long-term clinical follow up in medically intractable cluster headache

Primary Objective: To assess real-world long-term efficacy and tolerability of occipital nerve stimulation (ONS) in medically intractable chronic cluster headache patients Secondary Objectives: - To obtain real world data of effect of ONS on quality…