Search for a trial

A Randomized, Two-Period, Double-Blind Placebo-Controlled and Open-Label, Multicenter Extension Study to Determine the Long-Term Safety and Tolerability of JNJ-54861911 in Subjects in the Early Alzheimer*s Disease Spectrum

The primary objective of this study is to evaluate the long-term safety and tolerability of JNJ-54861911 in subjects in the early AD spectrum that have completed a Phase 1b or Phase 2 clinical trial with JNJ 54861911 (e.g., Study 54861911ALZ2002),…

Sensory processing in autism and childhood epilepsy

To study sensory processing and hyperexcitability in children with ASD and epilepsy using neurophysiological measurements (EEG/ERP).

The relationship between pain and cognitive functioning, of patients with neurodegenerative diseases such as Parkinson's disease, Multiple Sclerosis and Huntington's disease
Substudy: The relationship between pain, cognitive functioning, and motor activity in patients with multiple sclerosis

Various brain areas play a crucial role in both pain and cognition, supporting the existence of a close relationship between pain and cognition. Consequently, it is important to examine whether pain experience changes at the moment the patient shows…

Coping strategies in adults with a diagnosis of refractory epilepsy: Development, antecedents, and consequences.

Primary Objectives: To formulate answers to the following questions:Three main study objectives will be examined in the present project.1. What are the employed coping strategies in patients with refractory epilepsy and how do these develop over…

Optimizing lung imaging in people with Ataxia Telangiectasia applying improved MRI techniques.

The purpose of this research project is to improve the overall quality and resolution of the MRI images, to correct for movement effects during the procedure and to speed up the investigation. The goal is to enhance and standardize a technique…

Excretion balance, pharmacokinetics and metabolism of S44819 after single administration of [14C]-S44819 in young healthy male volunteers. A phase 1 monocentre open-label study.

The purpose of the study is to investigate the pharmacokinetics of S 44819. S 44819 is labeled with 14-Carbon (14C) and is thus radioactive (also called radiolabeled). In this way, S 44819 and its metabolites can be traced in blood, urine and feces…

Participation of children and youth after mild traumatic brain injury.

The aim of this study is to examine the daily level of activities and participation after LTH in children and adolescents (6-18 years) and to identify possible predictors. In addition, experimental research is done in a subgroup to measure the…

Brain Power: Functioning after traumatic brain injury (TBI) in children and youth

To establish the incidence and consequences (impairments op body functions, limitations in participation) of traumatic brain injury in children and youth in a region of The Netherlands as well as the incidence of the same symptoms in a group of…

Safeguarding the brain of our smallest children ;* an investigator-initiated randomised, blinded, multinational, phase II
feasibility clinical trial on near-infrared spectroscopy monitoring
combined with defined treatment guidelines versus
standard monitoring and treatment as usual in premature infants

The primary objective of the SafeBoosC trial is to examine if it is possible to stabilise the cerebral oxygenation of extremely preterm infants (gestational age < 28 wks) during the first 72 hours of life through the application of cerebral…

Prevention of renal and bladder damage in children with spina bifida by means of early injections with Botulinum-Toxin-A (Botox): a pilot study.

- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) prevent deterioration of the bladder and renal function?- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) decrease the need for an…

Predictors of mood fluctuations in patients with chronic migraine

The current study will examine psychological predictors of fluctuations in mood in the daily life of patients with CM. First, we will examine the role of within-subjects factors (headache, goal disturbance, rumination) in explaining daily…

Dutch Flutemetamol Study

Primary objective:1. To investigate the clinical value of [18F]Flutemetamol PET in memory clinic patients and especially those with suspicion of young onset dementia in terms ofa. change in (level of confidence of) diagnosis;b. impact on patient…

Reconstruction of the optic radiation using enhanced DTI compared to HARDI

In this study the potential of using the enhanced procedures for analyzing diffusion weighted data which were acquired according to clinical procedures is further investigated. The result is compared to the reconstruction of the OR based on high…

Examining wheelchair skills of children who are propelling a manual wheelchair

To develop and examine the test-retest reliability of a wheelchair skills test for children

Single-center, open-label, non-randomized study investigating the excretion balance, pharmacokinetics and metabolism of a single oral dose of [14C]-labeled RO5285119 in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent the study medication is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will…

Validation of the novel PET tracer [18F]PK209 in healthy volunteers: Dosimetry, test-retest, and specific binding to the NMDA receptor

The objective of this project is to assess the applicability of [18F]PK209 for in vivo imaging of the NMDA receptor.

A prospective randomised open label study to determine the best dose escalation scheme of dipyridamol added to acetylsalicylic acid, based on the side-effect headache, in patients starting secondary preventive therapy for stroke

To determine the best dose escalation scheme of dipyridamole added to acetylsalicylic acid, based on the side-effect headache, in patients starting secondary preventive therapy for stroke

Postural responses to balance perturbations in individuals with Supratentorial Stroke and Idiopathic Parkinson's Disease

In PD patients: To investigate the effect of Levodopa on postural responses after translational perturbations. These outcomes will be helpful to decide whether patients in the cohort study should be measured in the ON or OFF medication state. In…

An open-label, two-period, fixed sequence study to evaluate the effects of multiple oral doses of AFQ056 on the pharmacokinetics of a monophasic oral contraceptive in healthy female volunteers

* To examine how multiple oral doses of the test compound (an experimental medication) will be taken up by the body, metabolized and excreted by the body in combination with the oral contraception pill which consists of ethinyl-estradiol and…

Why humans fall: the next step to successful balance

In the proposed project we aim to predict falls in daily life and to identify both aging- and disease-related impairments that underlie impaired postural control and an increased risk of falling in daily life.