78 results
Primary Objective: To study the change on performance on executive function and memory function (as measured on Neurocart), after an active challenge with methylphenidate (monoaminergic) and galantamine (cholinergic), compared to placebo, in…
To study sensory processing and hyperexcitability in children with ASD and epilepsy using neurophysiological measurements (EEG/ERP).
Primary Objectives: To formulate answers to the following questions:Three main study objectives will be examined in the present project.1. What are the employed coping strategies in patients with refractory epilepsy and how do these develop over…
The purpose of this research project is to improve the overall quality and resolution of the MRI images, to correct for movement effects during the procedure and to speed up the investigation. The goal is to enhance and standardize a technique…
To establish the incidence and consequences (impairments op body functions, limitations in participation) of traumatic brain injury in children and youth in a region of The Netherlands as well as the incidence of the same symptoms in a group of…
Primary objective:1. To investigate the clinical value of [18F]Flutemetamol PET in memory clinic patients and especially those with suspicion of young onset dementia in terms ofa. change in (level of confidence of) diagnosis;b. impact on patient…
To develop and examine the test-retest reliability of a wheelchair skills test for children
In PD patients: To investigate the effect of Levodopa on postural responses after translational perturbations. These outcomes will be helpful to decide whether patients in the cohort study should be measured in the ON or OFF medication state. In…
In the proposed project we aim to predict falls in daily life and to identify both aging- and disease-related impairments that underlie impaired postural control and an increased risk of falling in daily life.
Discrimination of probable AD patients from healthy volunteers by ZK 6032924 PET imaging as evaluated by visual analysis of the brain distribution patterns and by SUV values in probable AD patients as compared to healthy volunteers for brain imaging…
Primary objective of the study:To find out which areas in the brain play a part in the maintenance of tinnitus, and what the roles of those areas are. This will be done using the AEP response in EEG recordings.Secundary objectives of the study:1. To…
The purpose of this research project is to assess whether affected PKD patients have brain abnormalities compared to healthy normal controls. Hypothesis: Paroxysmal kinesigenic dyskinesia affected individuals exhibit abnormal spontaneous activity of…
To examine neurocognition in 100 HIV1 seropositive patients on chronic effective cART using three different tests: the Montreal cognitive assessment (MoCA) , the International Aids Dementia scale (ADS) and extensive neuropsychological testing of…
Main objective is to study changes in in vivo blood viscosity during mild therapeutic hypothermia and rewarming in patients after cardiac arrest. Secondary objectives are to study the effects of cooling and rewarming on-Hemodynamic parameters-…
The main object of this study is:Optimization of the face-name association task, such that this task can be used to examine the prediction of postoperative memory failure in preoperative patients with epilepsy.Sub Objectives:- Investigation and…
In a randomized controlled trial, the effects of DHCA and ACP during complex neonatal cardiac surgery on organ function and injury will be compared, especially focusing on cerebral damage and neurological outcome. The primary research question is…
To set up a repository of genetic material from a large group of well phenotyped people with epilepsy patients to allow the case control association studies, and families for linkage studies, to analyze and detect genetic risk factors for epilepsy.
To investigate whether stress (chronic and acute) influences cognitive functioning in PD.
In the present study, we aim to estimate concordance between two biomarkers developed to interrogate the presence of brain amyloid deposition. This includes a new amyloid PET-tracer, [18F]Flutemetamol, and a CSF biomarker The objective of the…
The mean objective of this research project is the implementation in daily clinical practice of MEG as the examination of the first choice for the diagnosis of patients with suspicion of epilepsy. Furthermore, the current project links directly to…