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A multi-centre, double-blind, parallel-group, randomised controlled study to investigate efficacy, safety and tolerability of orally administered BI 409306 during a 12-week treatment period compared to placebo in patients with cognitive impairment due to Alzheimer's Disease.

The primary objective of this study is to assess efficacy and safety of BI 409306 at doses of 10 mg, 25 mg and 50 mg once daily, 25 mg twice daily compared to placebo over a 12-week treatment period in patients with the following criteria: mild…

APOLLO: A Phase 3 Multicenter, Multinational, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Patisiran (ALN-TTR02) in Transthyretin (TTR)-Mediated Polyneuropathy (Familial Amyloidotic Polyneuropathy-FAP)

This study aims to demonstrate the clinical efficacy of patisiran and to establish the safety of chronic dosing in ATTR patients with FAP.The primary objective of the study is to determine the efficacy of patisiran by evaluating the difference…

A Phase 2a Randomized, Double-blind, Placebo-Controlled, Parallel-Group, Multi-center Study Investigating the Safety and Tolerability of JNJ-54861911 in Subjects in the Early (Predementia) Alzheimer*s Disease Spectrum

This safety study in subjects in the early (predementia) AD spectrum is performed to investigate primarily the safety and tolerability of JNJ-54861911 during 6 months of treatment.

A phase I, randomised, double-blind, placebo-controlled study in patients with amyotrophic lateral sclerosis to further assess the safety and tolerability of intracerebroventricular administration of sNN0029 infusion solution.

The objective of the trial is to assess the safety and tolerability of i.c.v. administration of sNN0029 infusion solution at a dose of 4 µg per day delivered via a Medtronic SynchroMed® II Infusion System.

Prevention of renal and bladder damage in children with spina bifida by means of early injections with Botulinum-Toxin-A (Botox): a pilot study.

- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) prevent deterioration of the bladder and renal function?- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) decrease the need for an…

A double blind, double dummy, randomized, placebo-controlled, 4 period cross-over study to examine the effect of PF-063782865 on evoked pain endpoints in healthy volunteers using pregabalin as a positive control

To investigate the ability of PF-06372865 to demonstrate analgesic properties in healthy subjects for pre-specified primary endpoints using a panel of pain tests.

Predictors of mood fluctuations in patients with chronic migraine

The current study will examine psychological predictors of fluctuations in mood in the daily life of patients with CM. First, we will examine the role of within-subjects factors (headache, goal disturbance, rumination) in explaining daily…

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 26-Week, Phase 3 Study of Two Doses of EVP-6124 or Placebo in Subjects with Mild to Moderate Alzheimer*s Disease Currently or Previously Receiving an Acetylcholinesterase Inhibitor Medication

Primary ObjectivesTo evaluate the safety and efficacy of 2 fixed doses of EVP-6124 hydrochloride (HCl) ( 2 or 3 mg daily) compared to placebo for 26 weeks in subjects with mild to moderate dementia due to Alzheimer*s disease (AD) currently receiving…

Reconstruction of the optic radiation using enhanced DTI compared to HARDI

In this study the potential of using the enhanced procedures for analyzing diffusion weighted data which were acquired according to clinical procedures is further investigated. The result is compared to the reconstruction of the OR based on high…

A Double-Blind, Placebo-Controlled, 5-Way Crossover Study of EVP-6124 in a Scopolamine Challenge Model in Healthy Elderly Subjects

Primary objectives:To determine the exposure-response relationship of EVP-6124 over a range of plasma concentrations in a scopolamine-induced cognitive deficit model in healthy elderly subjects.Secundary objectives:To determine the exposure-response…

Single-center, open-label, non-randomized study investigating the excretion balance, pharmacokinetics and metabolism of a single oral dose of [14C]-labeled RO5285119 in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent the study medication is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will…

Validation of the novel PET tracer [18F]PK209 in healthy volunteers: Dosimetry, test-retest, and specific binding to the NMDA receptor

The objective of this project is to assess the applicability of [18F]PK209 for in vivo imaging of the NMDA receptor.

A double blind, double dummy, randomized, placebo-controlled, 5 period cross-over study to examine the effect of PF-06273340 on evoked pain endpoints in healthy volunteers using pregabalin and ibuprofen as positive controls

To investigate the ability of PF-06273340 to demonstrate analgesic properties in healthy subjects for pre-specified primary endpoints using a panel of pain tests.

A Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study of the Efficacy and Safety of Pregabalin as Adjunctive Therapy in Children 1 Month through <4 Years of Age with Partial Onset Seizures.

Primary Efficacy Objective* The primary objective of this study is to evaluate the efficacy of two dose levels of pregabalin compared to placebo as an adjunctive treatment in reducing the frequency of partial onset seizures in pediatric subjects 1…

A multi-centre, double-blind, parallel-group, randomized controlled study to investigate the efficacy, safety and tolerability of orally administred BI 409306 during a 12-week treatment period compared to placebo in patients with Alzheimer's disease.

The primary objective of this study is to assess efficacy and safety of BI 409306 at doses of 10 mg, 25 mg and 50 mg once daily, 25 mg twice daily compared to placebo over a 12-week treatment period in male and female patients at least 55 years of…

Health effects of sport participation in children and adolescents with a chronic disease or condition.
Sport-2-Stay-Fit (S2SF) study

The Sport-2-Stay-Fit (S2SF) Study will investigate if an after school sports program increase the sustainability of a standardized interval training program in children and adolescents with a physical disability or chronic disease.

A double blind, double dummy, randomized, placebo-controlled, 5 period cross-over study to examine the effect of PF-05089771 alone and in combination with pregabalin on evoked pain endpoints in healthy volunteers using pregabalin and ibuprofen as positive controls

To investigate the ability of PF-05089771 to demonstrate analgesic properties in healthy subjects for pre-specified primary endpoints using a panel of pain tests.

A multi-centre, open-label, follow-on study to assess long-term safety and tolerability of intracerebroventricular administration of sNN0029 in patients with amyotrophic lateral sclerosis

The objective of the trial is to assess the long-term safety and tolerability of intracerebroventricular administration of sNN0029 infusion solution at a dose of 4 µg/day delivered via a Medtronic SynchroMed® II Infusion System.

A 26- week Extension study of the safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication

Primary ObjectivesTo assess the safety of 2 fixed doses of EVP-6124 (2 or 3 mg daily) for up to 52 weeks in subjects withAlzheimer*s disease (AD) who complete (Day 182) studies EVP-6124-024 or EVP-6124-025Secondary ObjectivesTo assess the duration…

Pilot study: The retina as a potential window to visualize neuropathology in Alzheimer's disease.

This pilot study aims to investigate the retina, macula and optic nerve head with Optical Coherence Tomography (OCT) in AD patients in order to identify a neurodegenerative signature of AD in the eye. With Fundus Autofluorescence (FAF), amyloid…