209 results
In this research project, we will investigate the feasibility of multi-unit microneurography for the research of human muscle mechanoreceptors. We will therefore answer the following questions:1) How hard is it to find and maintain an effective…
1) Identify and further explore the structural and functional brain alterations in ALS patients, PSMA patients annd PLS patients in comparison to healthy controls and ALS mimic sydromes, both cross-sectional and longitudinal; 2) Explore anatomical…
The objective is to describe the nature and underlying (neuromuscular en biomechanical) factors of dysphagia in different neuromuscular diseases in relation to different consistencies of food. Identifying the contributing factors are starting points…
The two objectives of our study are:(i) to develop a disease model using stem cells, with which further research into the underlying disease mechanisms of ALS and future therapies can be done(ii) genetic modification of stem cells to correct or…
1. To determine the reproducibility and sensitivity of the EC of walking test in boys with DMD, in comparison with the reproducibility and sensitivity of the 6MWT. 2. To evaluate the one-year course of limitations in ambulation among boys with DMD,…
Primary ObjectiveTo evaluate the effect of a tailored behavioral change intervention comprising CBT and physical activity on participation (as measured by the DM1-Activ scale) for severely fatigued patients with myotonic dystrophy type 1 compared to…
Primary:The primary objective of the study is to evaluate the long-term safety profile of dexpramipexole in subjects with ALS.Secondary:The secondary objective of this study is to evaluate the longterm efficacy of dexpramipexole in this study…
The main objective of this study is to compare DTI findings of PPS patients with those of healthy controls. Secondary objective of this study is to correlate DTI findings with clinical data such as isometric muscle strength. Third objective is to…
Primary:To investigate the presence of disease-specific antimyenteric antibodies and to identify their target-antigen in patients with achalasia.Secondary:- To determine to what extent humoral autoimmunity is the etiological factor in idiopathic…
The aim of this study is to develop an immortalised B-cell line derived from MG patients. This antibody producing cell line will be used for different applications:- The establishment of new passive transfer disease models for MG- The identification…
We want to investigate if it is possible to set up the entire process of home mechanical ventilation outside the hospital. This means practically that the patients will not be admitted to the hospital. The goal of this study is to answer the…
1. What is the somatosensory profile of DM2 patients?2. What are the similarities and differences between the somatosensory profile of pain in myotonic dystrophy type 2 and fibromyalgia patients?
Identify and further explore the structural brain alterations in ALS patients in comparison to healthy controls and to investigate the correlations of anatomical changes with clinical variables.
To investigate the validity the dynamometer the KinCom in comparison to the Biodex dynamometer.
The purpose of this study concerns at a standardized way identifying the phenotype of patients with mt.3243A>G mutation, and relatives in the maternal line of patients with the mt.3243A>G mutation
To obtain more information on peripheral muscle properties that can account for the reduced exercise capacity in patients with PPS compared to healthy subjects, and to develop an alternative method for determining aerobic exercise capacity in…
Using state-of-the-art MR methods, this project aims to acquire a detailed understanding of the biochemical, structural and genetic background of the cognitive impairment in DMD and to determine whether the previously found differences between…
There are some unresolved issues that we intend to address in this project. We will examine 1) whether with locating the motorcortex with functional MRI, the best location of the electrodes can be predetermined, 2) how brain activity changes in the…
To describe the course of symptoms of BPS/IC after intravesical injection of Botox®.
This study will consist of two parts. In the primary observational part we will assess kinematic and kinetic walking patterns in Duchenne Muscular Dystrophy. Goal is to asses the correlation between progressive contractures and gait patterns. This…