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Effects of levosimendan on diaphragm contractility in healthy subjects

The primary objective of this proof of principle study is to determine the effect of levosimendan on the strength and endurance of the diaphragm in healthy subjects. The secondary objective is to gain insight in the neural activation and efficiency…

Pathophysiology of cold intolerance in different patient groups

Main objectiveTo describe the experienced pain sensations of temperature and to describe the different temperature sensitivity thresholds using Quantitative Sensory Test (QST) in the different patient groups.secondairy objectiveAs a measure of the…

Quality of Life and Rehabilitation Care in Amyotrofic Lateral Sclerosis.

(1) To study the efficacy of AET for improving activities and QoL in patients with ALS. (2) To identify generic and disease-specific determinants of effects. (3) To obtain insight into patients* , partners* and professionals' expectations of…

Non-invasive follow-up assessment of brain involvement in Duchenne muscular dystrophy

Using state-of-the-art MR methods, this project aims to acquire a detailed understanding of the biochemical, structural and genetic background of the cognitive impairment in DMD and to determine whether the previously found differences between…

Contractures and dynamic splinting in Duchenne Muscular Dystrophy:
Effects on gait economy.

This study will consist of two parts. In the primary observational part we will assess kinematic and kinetic walking patterns in Duchenne Muscular Dystrophy. Goal is to asses the correlation between progressive contractures and gait patterns. This…

A randomized clinical trial of group medical appointments for patients with chronic neuromuscular disease. A comparison with usual care in terms of quality of life and cost-effectiveness

To compare group medical appointment as a novel approach in care for chronic neuromuscular patients with conventional outpatient visits, in terms of health outcomes and costs.