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A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy of Natalizumab on Reducing Disability Progression in Subjects With Secondary Progressive Multiple Sclerosis, With optional Open-label Extension

Part 1:The primary objective of the study is to investigate whether treatment with natalizumab slows the accumulation of disability not related to relapses in subjects with SPMS. The secondary objectives of this study are to determine in this study…

Shoulder load and daily activities compared between power assisted and manual wheelchair propulsion.

The primary objective is to compare forces and moments acting on the shoulder of manual wheelchair users during power assisted wheelchair propulsion and manual wheelchair propulsion and the perceived upper extremity load. The secondary objectives…

A Phase 1, 2-part, Open Label Pharmacokinetic and Safety Study to Evaluate Dose Proportionality and Accumulation of Firdapse® (3,4-Diaminopyridine Phosphate) after Single and Multiple Oral Doses in Healthy Volunteers

Primary:To assess the safety and tolerability of Firdapse after single and multiple doses Secondary:Part 1 only: To determine the dose-related PK profile of single, escalating doses of Firdapse;Part 2 only: To assess the steady-state plasma PK and…

Function of the neuromuscular junction in patients with spinal muscular atrophy (SMA); A cohort study on the function of the neuromuscular junction in Dutch patients with spinal muscular atrophy to elucidate the possible role of the neuromuscular junction in the pathophysiology of spinal muscular atrophy

The main objective of this prospective cohort study of patients with proximal SMA in the Netherlands is to investigate the function of the neuromuscular junction by means of repetitive nerve stimulation (RNS).

A novel neurophysiological measurement (MUNIX) in neuromuscular disorders; test-retest reliability and longitudinal follow up measurements in ALS patients

PrimaryTo investigate the inter-rater and intra-rater variability of a novel neurophysiological measurement (Motor Unit Number Index, MUNIX) for estimation of functioning motor units, in healthy controls and ALS patientsSecondaryTo evaluate the…

A comparison study of Dutch and Norwegian Myasthenia Gravis patients: epidemiological and clinical aspects.

Objective: to identify potential predisposing and modifying factors of MG in order to improve understanding of the mechanisms of disease, diagnostics and treatment.

Muscle biopsie for Acute Complex Regional Pain Syndrome Type I from one extremity for mitochondrial research

Does mitochondrial dysfunction play an important role in the pathofysiology of patients with Complex Regional Pain Syndrome Type I ?

6 minutes assisted leg and arm cycling test: feasibility, validity, test-retest responsivity and responsivity in patients with neuromuscular and metabolic disorders

2.1 Primary Objectives: 1) To test the feasibility of the six minute assisted leg and arm cycling test in patients aged 6-18 years with Duchenne muscular dystrophy (DMD), Beckers muscular dystrophy (BMD), Limb Girdle muscular dystrophy (LGMD),…

our study is part of the multicentre study "e-OPMD": bringing focus to OPDM research in Europe.
"Pathophysiology and therapeutic approaches in Oculopharyngeal Muscular Dystrophy (OPMD)"

Within this complete European consortium animal models as well as patient material are utilized, in order to uncover the pathogenic pathways in OPMD that are at the centre of the disease, eventually in order to design rational evidence based…

Imaging in motor neuron diseases;
biomarker research with MRI

1) Identify and further explore the structural and functional brain alterations in ALS patients, PSMA patients annd PLS patients in comparison to healthy controls and ALS mimic sydromes, both cross-sectional and longitudinal; 2) Explore anatomical…

A randomized, double-blind, placebo-controlled, multi-center study of the safety and efficacy of Dexpramipexole in subjects with amyotrophic lateral sclerosis.

Primary:The primary objective of the study is to evaluate the efficacy of oral administration of dexpramipexole 150 mg twice daily compared to placebo for 12 months in subjects with ALS.Secondary:The secondary objectives of the study are to evaluate…